{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:01:29Z","timestamp":1785416489498,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine final height (FH), body mass index (BMI) changes, and age at menarche in obese girls with idiopathic central precocious puberty (CPP) treated with gonadotropin\u2010releasing hormone analogue (GnRHa), compared with their normal\u2010weight counterparts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Patients and Measurements<\/jats:title>\n                    <jats:p>Height outcomes, FH, BMI changes and age at menarche of girls with idiopathic CPP treated with GnRHa who had reached FH were reviewed. Comparisons were performed between the overweight\/obese and normal\u2010weight groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 726 patients were enroled (269 overweight\/obese and 457 normal\u2010weight). At diagnosis, overweight\/obese girls were taller (median (interquartile range) height standard deviation score (SDS): 1.53 (0.69, 2.12) versus 0.80 (0.28, 1.40),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and had greater degree of bone age advancement (2.5 (1.8, 3.2) vs. 2.0 (1.1, 2.7) years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The overweight\/obese group had greater height gain (FH\u2014initial predicted adult height) following GnRHa treatment (8.0 (4.4, 11.5) vs. 6.8 (3.6, 10.7) cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). BMI SDSs at FH were less than those at diagnosis in both groups (overweight\/obese: 1.26 (0.52, 2.07) vs. 1.70 (1.23, 2.51), and normal\u2010weight: \u22120.23 (\u22120.79, 0.47) versus 0.26 (\u22120.35, 0.67),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Notably, 109 overweight\/obese girls had normalised BMI SDS at FH. The interval from GnRHa discontinuation to menarche was comparable between the two groups (14.4 (8.4, 19.2) vs. 14.4 (9.6, 19.2) months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.961).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GnRHa therapy had a beneficial effect on height gain in both CPP girls with overweight\/obesity and normal weight. BMI SDSs at FH were less than those at diagnosis in both groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70195","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:05:14Z","timestamp":1785413114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcomes of Gonadotropin\u2010Releasing Hormone Analogue Therapy in Central Precocious Puberty: A Comparative Analysis of Obese and Normal\u2010Weight Girls"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-7367","authenticated-orcid":false,"given":"Natee","family":"Sakornyutthadej","sequence":"first","affiliation":[{"name":"Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital Mahidol University Samut Prakan Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirawat","family":"Pruksasri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-2963","authenticated-orcid":false,"given":"Pat","family":"Mahachoklertwattana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-2345","authenticated-orcid":false,"given":"Sarunyu","family":"Pongratanakul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5701-0211","authenticated-orcid":false,"given":"Orapan","family":"Upakankul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-6210","authenticated-orcid":false,"given":"Preamrudee","family":"Poomthavorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.beem.2018.05.008","article-title":"Central Precocious Puberty: From Genetics to Treatment","volume":"32","author":"Aguirre R. 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