{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T18:43:15Z","timestamp":1786128195815,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Kisspeptin\u20101 and Kisspeptin\u201054 are key regulators of the hypothalamic\u2013pituitary\u2013gonadal axis and may play a role in male reproductive function. This study aimed to evaluate the association between seminal plasma kisspeptin levels and male infertility, and to examine their relationships with semen parameters and oxidative stress markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty men attending an in vitro fertilization centre were classified into normozoospermia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), oligoasthenoteratozoospermia (OAT) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918) and azoospermia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) groups according to WHO 2021 criteria. Seminal plasma Kisspeptin\u20101 and Kisspeptin\u201054 levels were measured using ELISA. Oxidative stress parameters, including total antioxidant capacity (TAC), total oxidant capacity (TOC) and oxidative stress index (OSI), were assessed using spectrophotometric methods. Correlation and regression analyses were performed to evaluate associations between variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Kisspeptin\u20101 and Kisspeptin\u201054 levels showed a progressive decrease with increasing infertility severity (normozoospermia\u2192OAT\u2192azoospermia;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Both kisspeptins were positively associated with sperm concentration and progressive motility, and negatively associated with TOC and OSI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). TAC levels were higher in normozoospermic men, whereas oxidative load was increased in azoospermic individuals. Regression analyses indicated that seminal kisspeptin levels were significantly associated with sperm concentration and progressive motility. Parallel alterations in kisspeptin levels and oxidative stress markers suggest a relationship between these peptides and the seminal microenvironment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Seminal plasma kisspeptin levels are associated with semen quality and oxidative stress parameters in male infertility. These findings suggest that kisspeptin may represent a potential biomarker candidate for the evaluation of male infertility, although further validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70199","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:49:53Z","timestamp":1786124993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seminal Plasma Kisspeptin\u20101 and Kisspeptin\u201054 Levels Are Associated With Semen Parameters and Oxidative Stress in Male Infertility"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-5869","authenticated-orcid":false,"given":"Oya","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Malatya Turgut \u00d6zal University Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, International Faculty of Medicine Istanbul Medipol University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Macit","sequence":"additional","affiliation":[{"name":"In Vitro Fertilization Center Istanbul Okan University Hospital Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16793-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.230232"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.03.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17600"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.925206"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2015.30.2.124"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5129263"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-025-03644-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00198"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666180129112406"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"12","article-title":"Insight Into the Serum Kisspeptin Levels in Infertile Males","volume":"18","author":"Ramzan M. H.","year":"2015","journal-title":"Archives of Iranian Medicine"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101769"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12598"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12301-023-00377-z"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081203"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13057"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031514"},{"key":"e_1_2_11_19_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082958"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/endocrines3020015"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493406"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113618"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14103284"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2011.01177.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160902155434"},{"issue":"8","key":"e_1_2_11_27_1","first-page":"1227","article-title":"Kisspeptin Levels in Infertile Male Subjects With Abnormal Sperm Parameters","volume":"69","author":"Rehman R.","year":"2019","journal-title":"Journal of the Pakistan Medical Association"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.05.012"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.22092\/ARI.2021.356811.1918"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:49:55Z","timestamp":1786124995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":28,"alternative-id":["10.1111\/cen.70199"],"URL":"https:\/\/doi.org\/10.1111\/cen.70199","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cen.70199"}}