{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:25:17Z","timestamp":1787743517122,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glucocorticoid (GC) replacement in Addison's disease (AD) usually fails to mimic physiological circadian cortisol rhythm. Recurrent hypercortisolemia may contribute to central obesity, hyperglycemia and dyslipidemia, which could explain cardiovascular mortality in AD. Steroid excess alters lipid profile, while effects of the replacement doses remain inconsistent, which led us to evaluate serum lipids in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross\u2010sectional study in patients treated for autoimmune AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>The study comprised 66 patients diagnosed &lt;1 year (AD1), 97 diagnosed &gt;1 year (AD2) before the study and 96 matched controls (CON), excluding individuals with diabetes, thyroid dysfunction and lipid\u2010lowering treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Investigations included physical examination and biochemical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients were on immediate\u2010release hydrocortisone (HC), mean\u2009\u00b1\u2009SD 22.7\u2009\u00b1\u20096.6\u2009mg\/day. AD1 presented significantly lower HC dosage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001), higher TSH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.046) and lower fasting glucose (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.005) versus AD2 and CON. Recently treated patients demonstrated significantly lower total cholesterol (TC), LDL\u2010C and triglyceride (TG) levels\n                      <jats:italic>versus<\/jats:italic>\n                      both AD2 and CON, who displayed similar lipid profile. Only HDL\u2010C was significantly higher in AD2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Hyperlipidemia was found in 62.5% CON subjects, 45.5% AD1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), and 60.8% AD2 patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.811). Age was strongly correlated with TC and LDL\u2010C in AD and CON. Daily HC dose correlated with TC and LDL\u2010C in both AD1 and AD2, and with HDL\u2010C in AD1, and multivariable regression confirmed its predictive value with regard to TC and LDL\u2010C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The risk of hyperlipidemia in patients receiving GC replacement does not seem elevated. Nonetheless, metabolic complications should be screened to improve long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70203","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:14:02Z","timestamp":1787742842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Lipid Profile in Patients With Primary Adrenal Insufficiency Receiving Glucocorticoid Replacement"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-7074","authenticated-orcid":false,"given":"Marta","family":"Fichna","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases Pozna\u0144 University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Fichna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Diabetes, Auxology and Obesity Pozna\u0144 University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sumi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Diabetes, Auxology and Obesity Pozna\u0144 University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boles\u0142aw","family":"G\u0119barski","sequence":"additional","affiliation":[{"name":"Regional Outpatient Medical Centre Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Rucha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases Pozna\u0144 University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12162"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0874"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-2-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0076"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvaf186"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.06.012.d"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0320059"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-005129"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313478200"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00045.2010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02168.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(88)90067-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345773"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090768"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01324"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-010-9359-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2190-3735"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.67.4.730"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9120(01)00263-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12422"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-16-0081"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7196\/samj.7979"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00420"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01994.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0477"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2522"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.3464"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2025.05.004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0002"},{"key":"e_1_2_9_32_1","unstructured":"S.SubramanianHypertriglyceridemia: Pathophysiology Role of Genetics Consequences and Treatment. [Updated 2024 Jan 8]. In: Feingold KR Adler RA Ahmed SF et al.editors. Endotext [Internet]. South Dartmouth (MA): MDText.com Inc; 2000."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-1-39"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02298"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad136"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-025-04192-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.70149"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:14:03Z","timestamp":1787742843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":36,"alternative-id":["10.1111\/cen.70203"],"URL":"https:\/\/doi.org\/10.1111\/cen.70203","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2026-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cen.70203"}}