{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:37Z","timestamp":1791528577031,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015223","name":"Danish Diabetes and Endocrine Academy","doi-asserted-by":"publisher","award":["NNF22SA0079901"],"award-info":[{"award-number":["NNF22SA0079901"]}],"id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF25OC0100796"],"award-info":[{"award-number":["NNF25OC0100796"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) risk is elevated in transgender individuals during gender\u2010affirming hormone therapy (GAHT) with expected different mechanisms between T\u2010 and E2\u2010based GAHT. We investigated prospective changes in cardiometabolic proteins relating to complement, inflammation, and transport during GAHT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective clinical study with assessment at baseline and after 1 year of GAHT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>The main study population comprised 55 GAHT\u2010na\u00efve individuals (34 TM, 21 TF). An additional 35 GAHT\u2010ongoing individuals (26 TM, 9 TF) were included as a cross\u2010sectional comparison group at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>19 cardiometabolic proteins relating to atherosclerotic and thrombotic processes were analysed using targeted proteomics. Body composition was assessed by dual\u2010energy X\u2010ray absorptiometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In GAHT\u2010na\u00efve TM individuals, the mean age at baseline was 27 years and median BMI was 26.5 (22.3\u201328.9) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Following T\u2010based GAHT, complement factor H and B, 3, 4b, and transport proteins (sex hormone\u2010binding globulin, ceruloplasmin, corticosteroid\u2010binding globulin, vitamin\n                      <jats:sc>D<\/jats:sc>\n                      \u2010binding protein, vitronectin, and afamin) decreased, and transthyretin increased. In GAHT\u2010na\u00efve TF individuals, the mean age at baseline was 27 years and median BMI was 21.5 (20.3\u201323.6) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Following E2\u2010based GAHT, complement factor H and B, 3, 4b, 9, C\u2010reactive protein, immunoglobulin heavy constant alpha 1 (IGHA1), and transport proteins increased. In cross\u2010sectional analyses, complement factor H and B, 3, 4b, 9, C\u2010reactive protein, IGHA1, and afamin were higher in GAHT\u2010ongoing TF individuals at baseline compared to GAHT\u2010na\u00efve TF individuals at 1 year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T\u2010 and E2\u2010based GAHT were associated with opposite directional changes in cardiometabolic protein profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials. gov (Identifier: NCT04254354, NCT05169762).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70209","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:58:52Z","timestamp":1791525532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic Protein Profile Changes During Gender\u2010Affirming Hormone Therapy: A Prospective Clinical Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1310-1455","authenticated-orcid":false,"given":"Emilie Bukh","family":"Madsen","sequence":"first","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-7054","authenticated-orcid":false,"given":"Louise Lehmann","family":"Christensen","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2160-8092","authenticated-orcid":false,"given":"Sara Ravn","family":"Bach","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Sk\u00f8ttrup","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1422-2261","authenticated-orcid":false,"given":"Mathilde Kamp","family":"N\u00f8rlund","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-6120","authenticated-orcid":false,"given":"Tine Taulbjerg","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-9673","authenticated-orcid":false,"given":"Guy","family":"T'Sjoen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Pernille","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-5605","authenticated-orcid":false,"given":"Camilla Viola Buskbjerg","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"Department of Gynaecology and Obstetrics Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-0961","authenticated-orcid":false,"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-9504","authenticated-orcid":false,"given":"Marianne Skovsager","family":"Andersen","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-590X","authenticated-orcid":false,"given":"Martin","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Biochemistry Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-8025","authenticated-orcid":false,"given":"Dorte","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Southern Denmark Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1080\/26895269.2022.2100644","article-title":"Standards of Care for the Health of Transgender and Gender Diverse People, Version 8","volume":"23","author":"Coleman E.","year":"2022","journal-title":"International Journal of Transgender Health"},{"issue":"11","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1007\/s00125-024-06212-6","article-title":"Transgender Healthcare: Metabolic Outcomes and Cardiovascular Risk","volume":"67","author":"Glintborg D.","year":"2024","journal-title":"Diabetologia"},{"issue":"2","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1093\/ejendo\/lvad170","article-title":"Cardiovascular Disease in Transgender People: A Systematic Review and Meta\u2010Analysis","volume":"190","author":"Zijverden L. M.","year":"2024","journal-title":"European Journal of Endocrinology"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1530\/EJE-22-0306","article-title":"Cardiovascular Risk in Danish Transgender Persons: A Matched Historical Cohort Study","volume":"187","author":"Glintborg D.","year":"2022","journal-title":"European Journal of Endocrinology"},{"issue":"11","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/CIRCULATIONAHA.118.038584","article-title":"Occurrence of Acute Cardiovascular Events in Transgender Individuals Receiving Hormone Therapy","volume":"139","author":"Nota N. M.","year":"2019","journal-title":"Circulation"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf837"},{"issue":"4","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.119.005597","article-title":"Cardiovascular Disease Risk Factors and Myocardial Infarction in the Transgender Population","volume":"12","author":"Alzahrani T.","year":"2019","journal-title":"Circulation Cardiovascular Quality and Outcomes"},{"issue":"4","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.7326\/M17-2785","article-title":"Cross\u2010Sex Hormones and Acute Cardiovascular Events in Transgender Persons: A Cohort Study","volume":"169","author":"Getahun D.","year":"2018","journal-title":"Annals of Internal Medicine"},{"issue":"6","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1161\/CIR.0000000000001003","article-title":"Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse: A Scientific Statement From the American Heart Association","volume":"144","author":"Streed C. G.","year":"2021","journal-title":"Circulation"},{"issue":"6","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/fcp.12806","article-title":"Adverse Effects of Gender\u2010Affirming Hormonal Therapy in Transgender Persons: Assessing Reports in the French Pharmacovigilance Database","volume":"36","author":"Yelehe M.","year":"2022","journal-title":"Fundamental & Clinical Pharmacology"},{"issue":"9","key":"e_1_2_11_12_1","article-title":"Inflammation in Cardiovascular Disease: A Comprehensive Review of Biomarkers and Therapeutic Targets","volume":"15","author":"Gupta L.","year":"2023","journal-title":"Cureus"},{"issue":"9","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay Between Inflammation and Thrombosis in Cardiovascular Pathology","volume":"18","author":"Stark K.","year":"2021","journal-title":"Nature Reviews Cardiology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2022.03.014","article-title":"The Multifaceted Impact of Complement on Atherosclerosis","volume":"351","author":"Kiss M. G.","year":"2022","journal-title":"Atherosclerosis"},{"issue":"5","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1357-2725(99)00005-9","article-title":"Vitronectin","volume":"31","author":"Schvartz I.","year":"1999","journal-title":"International Journal of Biochemistry & Cell Biology"},{"issue":"10","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.3324\/haematol.2019.226241","article-title":"Vitronectin Stabilizes Intravascular Adhesion of Neutrophils by Coordinating \u03b22 Integrin Clustering","volume":"106","author":"Gabriele Zuchtriegel Z.","year":"2021","journal-title":"Haematologica"},{"issue":"1","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cca.2005.12.015","article-title":"Vitronectin in Atherosclerotic Disease","volume":"368","author":"Ekmek\u00e7i \u00d6. B.","year":"2006","journal-title":"Clinica Chimica Acta"},{"issue":"3","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0261312","article-title":"The Effect of Transdermal Gender\u2010Affirming Hormone Therapy on Markers of Inflammation and Hemostasis","volume":"17","author":"Schutte M. H.","year":"2022","journal-title":"PLoS One"},{"issue":"2","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.fertnstert.2020.08.002","article-title":"Testosterone Administration Increases Leukocyte\u2010Endothelium Interactions and Inflammation in Transgender Men","volume":"115","author":"Iannantuoni F.","year":"2021","journal-title":"Fertility and Sterility"},{"issue":"1","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvae163.1699","article-title":"7820 Immune System Adaptation During Gender\u2010Affirming Testosterone Treatment","volume":"8","author":"Lakshmikanth T.","year":"2024","journal-title":"Journal of the Endocrine Society"},{"issue":"4","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5152\/erp.2023.23256","article-title":"Effect of Cross\u2010Sex Hormone Therapy on Hematological Parameters in Transmen: A 1\u2010Year Follow\u2010Up Study","volume":"27","author":"Elbasan O.","year":"2023","journal-title":"Endocrinology Research and Practice"},{"issue":"5","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/ejendo\/lvaf038","article-title":"The Influence of Gender\u2010Affirming Hormone Therapy on Serum Concentrations of Hormone\u2010Binding Proteins","volume":"192","author":"Stangl T. A.","year":"2025","journal-title":"European Journal of Endocrinology"},{"issue":"4","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/clinchem\/hvac209","article-title":"Sex Hormone\u2010Binding Globulin and Risk of Coronary Heart Disease in Men and Women","volume":"69","author":"Li J.","year":"2023","journal-title":"Clinical Chemistry"},{"issue":"4","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/jth.15256","article-title":"Effect of Gender\u2010Affirming Hormone Use on Coagulation Profiles in Transmen and Transwomen","volume":"19","author":"Scheres L. J. J.","year":"2021","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2025.03.006"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201024\u20100222"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.endmts.2024.100201","article-title":"Platelet Activation and Inflammation in Transgender Women Using Hormone Therapy","volume":"16","author":"Zijverden L. M.","year":"2024","journal-title":"Endocrine and Metabolic Science"},{"issue":"10","key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s44161-024-00545-6","article-title":"Measured and Genetically Predicted Protein Levels and Cardiovascular Diseases in UK Biobank and China Kadoorie Biobank","volume":"3","author":"Lind L.","year":"2024","journal-title":"Nature Cardiovascular Research"},{"issue":"12","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/s44161-024-00567-0","article-title":"Integrative Proteomic Analyses Across Common Cardiac Diseases Yield Mechanistic Insights and Enhanced Prediction","volume":"3","author":"Schuermans A.","year":"2024","journal-title":"Nature Cardiovascular Research"},{"issue":"5","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s00125-016-3869-8","article-title":"First\u2010Trimester Multimarker Prediction of Gestational Diabetes Mellitus Using Targeted Mass Spectrometry","volume":"59","author":"Ravnsborg T.","year":"2016","journal-title":"Diabetologia"},{"issue":"3","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214457","article-title":"First\u2010Trimester Proteomic Profiling Identifies Novel Predictors of Gestational Diabetes Mellitus","volume":"14","author":"Ravnsborg T.","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/dom.16148","article-title":"The Cardio\u2010Metabolic Protein Profile Is Associated With Development of Type 2 Diabetes at Long Term Follow\u2010Up After Gestational Diabetes Mellitus: Results From the OGFUS Study","volume":"27","author":"Hallig S. J.","year":"2025","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"12","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-045714","article-title":"Masculinising Testosterone Treatment and Effects on Preclinical Cardiovascular Disease, Muscle Strength and Power, Aggression, Physical Fitness and Respiratory Function in Transgender Men: Protocol for a 10\u2010year, Prospective, Observational Cohort Study in Denmark at the Body Identity Clinic (BIC)","volume":"10","author":"Lehmann Christensen L.","year":"2020","journal-title":"BMJ Open"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1111\/andr.13832","article-title":"Cardiac Function and Coronary Plaque Development Following Masculinizing Gender\u2010Affirming Hormone Therapy: A Prospective Cohort Study","volume":"13","author":"Buhl L. F.","year":"2025","journal-title":"Andrology"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.70132"},{"issue":"11","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1210\/jc.2017-01658","article-title":"Endocrine Treatment of Gender\u2010Dysphoric\/Gender\u2010Incongruent Persons: An Endocrine Society Clinical Practice Guideline","volume":"102","author":"Hembree W. C.","year":"2017","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The Redcap Consortium: Building An International Community of Software Platform Partners","volume":"95","author":"Harris P. A.","year":"2019","journal-title":"Journal of Biomedical Informatics"},{"issue":"2","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap)\u2010\u2010A Metadata\u2010Driven Methodology and Workflow Process for Providing Translational Research Informatics Support","volume":"42","author":"Harris P. A.","year":"2009","journal-title":"Journal of Biomedical Informatics"},{"issue":"7","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: An Open Source Document Editor for Creating and Analyzing Targeted Proteomics Experiments","volume":"26","author":"MacLean B.","year":"2010","journal-title":"Bioinformatics"},{"issue":"3","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1046\/j.1365-2249.2000.01329.x","article-title":"The Effect of Testosterone Replacement Treatment on Immunological Features of Patients With Klinefelter's Syndrome","volume":"121","author":"Ko\u00e7ar I. H.","year":"2000","journal-title":"Clinical and Experimental Immunology"},{"issue":"10","key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.3390\/nu12103219","article-title":"Ceruloplasmin and Coronary Heart Disease\u2010A Systematic Review","volume":"12","author":"Arenas de Larriva A. P.","year":"2020","journal-title":"Nutrients"},{"issue":"10","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2337\/dc17-0201","article-title":"Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals","volume":"40","author":"Kollerits B.","year":"2017","journal-title":"Diabetes Care"},{"issue":"7","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/humrep\/deg292","article-title":"Association of Serum Complement (C3, C4) and Immunoglobulin (Igg, Igm) Levels With Hormone Replacement Therapy in Healthy Post\u2010Menopausal Women","volume":"18","author":"Yilmazer M.","year":"2003","journal-title":"Human Reproduction"},{"issue":"3","key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.maturitas.2009.01.009","article-title":"Effects of High Dose Oestrogen Therapy on Circulating Inflammatory Markers","volume":"62","author":"Wilson R.","year":"2009","journal-title":"Maturitas"},{"issue":"7","key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/GME.0000000000000296","article-title":"Hormone Therapy and Hemostasis Among Postmenopausal Women: A Review","volume":"21","author":"Canonico M.","year":"2014","journal-title":"Menopause"},{"issue":"9291","key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(01)06522-9","article-title":"Risk of Venous Thromboembolism With Cyproterone or Levonorgestrel Contraceptives","volume":"358","author":"Vasilakis\u2010Scaramozza C.","year":"2001","journal-title":"Lancet"},{"issue":"4","key":"e_1_2_11_47_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2026.106648","article-title":"Feminizing and Masculinizing Gender\u2010Affirming Hormone Therapy Affects Fibrin Clot Characteristics in Opposite Directions","volume":"10","author":"B\u00f8gehave M.","year":"2026","journal-title":"Research and Practice in Thrombosis and Haemostasis"},{"issue":"1","key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41440-022-01067-z","article-title":"Incidence of Hypertension in Young Transgender People After a 5\u2010year Follow\u2010Up: Association With Gender\u2010Affirming Hormonal Therapy","volume":"46","author":"Martinez\u2010Martin F. J.","year":"2023","journal-title":"Hypertension Research"},{"issue":"7","key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.jsxm.2021.05.003","article-title":"Anti\u2010Androgenic Effects Comparison Between Cyproterone Acetate and Spironolactone in Transgender Women: A Randomized Controlled Trial","volume":"18","author":"Burinkul S.","year":"2021","journal-title":"Journal of Sexual Medicine"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:58:59Z","timestamp":1791525539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":48,"alternative-id":["10.1111\/cen.70209"],"URL":"https:\/\/doi.org\/10.1111\/cen.70209","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"2026-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cen.70209"}}