{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:58:25Z","timestamp":1790866705367,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Growth hormone deficiency (GHD) is an important cause of growth failure in children. Although recombinant human growth hormone (rhGH) promotes catch\u2010up growth, longitudinal differences in treatment response between isolated growth hormone deficiency (IGHD) and combined pituitary hormone deficiency (CPHD) remain unclear. This study compared longitudinal growth trajectories during rhGH therapy between IGHD and CPHD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Patients<\/jats:title>\n                    <jats:p>A retrospective cohort study included 72 IGHD and 48 CPHD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Height standard deviation score (SDS) was assessed at baseline and after 12, 24, 36 and 48 months of rhGH therapy. Longitudinal trajectories were analysed using linear mixed\u2010effects models adjusted for age at treatment initiation, bone age, BMI SDS and pituitary MRI findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CPHD patients had more severe growth impairment at baseline than those with IGHD (height SDS: \u22125.00\u2009\u00b1\u20091.57 vs. \u22123.20\u2009\u00b1\u20091.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, CPHD demonstrated greater catch\u2010up growth, achieving larger cumulative height SDS gains after 48 months (3.10\u2009\u00b1\u20091.36 vs. 1.92\u2009\u00b1\u20090.87 SDS;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mixed\u2010effects modelling confirmed significantly different longitudinal growth trajectories (time\u2010by\u2010diagnosis interaction:\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u200966.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adjusted height SDS improved from \u22123.40 to \u22121.49 in IGHD and from \u22124.56 to \u22121.55 in CPHD. At 48 months, the adjusted CPHD\u2013IGHD difference was \u22120.06 SDS (95% CI, \u22120.63 to 0.51), consistent with substantial convergence of the two growth trajectories. Older age at treatment initiation and abnormal pituitary MRI findings were independently associated with lower height SDS across follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite more severe baseline growth impairment, children with CPHD experienced greater catch\u2010up growth during rhGH therapy, resulting in substantial convergence of longitudinal height SDS trajectories toward those of children with IGHD over 4 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70215","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:32:27Z","timestamp":1790865147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Converging Growth Trajectories During Recombinant Human Growth Hormone Therapy in Children With Isolated and Combined Pituitary Hormone Deficiency"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0418-2613","authenticated-orcid":false,"given":"Chi Dung","family":"Vu","sequence":"first","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"},{"name":"Hanoi Medical University Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8327-916X","authenticated-orcid":false,"given":"Quang Duy","family":"Pham","sequence":"additional","affiliation":[{"name":"Faculty of Sciences University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Thao","family":"Bui","sequence":"additional","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1102-9626","authenticated-orcid":false,"given":"Ngoc Khanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"},{"name":"Deparment of Pediatrics Thai Nguyen Uiniversity of Medicine and Pharmacy Phan Dinh Phung Thai Nguyen Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1404-0328","authenticated-orcid":false,"given":"Thi Bich Ngoc","family":"Can","sequence":"additional","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"},{"name":"Vietnam University of Traditional Medicine Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Hang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Lan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5359-9477","authenticated-orcid":false,"given":"Thi Chi Mai","family":"Tran","sequence":"additional","affiliation":[{"name":"Hanoi Medical University Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Duc","family":"Bui","sequence":"additional","affiliation":[{"name":"Pediatric Center Bach Mai Hospital Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-308X","authenticated-orcid":false,"given":"Thu Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center of Endocrinology, Metabolism, Genetic\/Genomics and Molecular Therapy Vietnam National Children's Hospital Ha Noi Vietnam"},{"name":"Hanoi Medical University Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2016-0382"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2016-1101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101556"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2013.09.02.136"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.84852"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2011-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac517"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e90"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329161"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02378.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3059"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","DOI":"10.1002\/9781119513469","volume-title":"Applied 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