{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:42:41Z","timestamp":1761986561881,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical & Exp Neuroim"],"published-print":{"date-parts":[[2022,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Guillain\u2013Barr\u00e9 syndrome (GBS) is an acute monophasic immune\u2010mediated polyradiculoneuropathy, preceded by gastrointestinal or respiratory infections in up to two\u2010thirds of patients. On rare occasions, people develop GBS after vaccination, but no causal association has been proven. In the current coronavirus disease 2019 (COVID\u201019) pandemic, some cases have been reported associating COVID\u201019 vaccine with GBS.<\/jats:p><\/jats:sec>Case presentation<\/jats:title>We report a case of a 62\u2010year\u2010old woman with GBS after the first dose of the Oxford\/AstraZeneca vaccine against SARS\u2010CoV\u20102. The symptoms started 3\u00a0weeks after the vaccine, and were characterized by ascending and progressive paresthesia in the upper and lower limbs, followed by loss of strength of the upper limbs and dysphagia for solids. The hypothesis of GBS was confirmed by clinical presentation compatible with albuminocytologic dissociation in cerebrospinal fluid and based on the Brighton criteria level\u00a02. The treatment was a 5\u2010day course of intravenous immunoglobulin with an improvement of symptoms.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In the absence of other causes, the diagnosis of GBS was made, with evidence of a clear temporal association with COVID\u201019 vaccine. However, a cautious position is important when assigning a particular side\u2010effect directly to a vaccine. It is important to emphasize that it is a temporal association only and the benefits of COVID\u201019 vaccination continue to outweigh the possible consequences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen3.12678","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T22:54:59Z","timestamp":1634511299000},"page":"92-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Guillain\u2013Barr\u00e9 syndrome after coronavirus disease 2019 vaccine: A temporal association"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-1989","authenticated-orcid":false,"given":"Gustavo Figueiredo","family":"da Silva","sequence":"first","affiliation":[{"name":"Department of Medicine University of the Region of Joinville (UNIVILLE) Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Figueiredo","family":"da Silva","sequence":"additional","affiliation":[{"name":"Neurology Service Internal Medicine Department Hospital Municipal S\u00e3o Jos\u00e9 Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raddib Eduardo Noleto da Nobrega","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Neurology Service Internal Medicine Department Hospital Municipal S\u00e3o Jos\u00e9 Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Romancini","sequence":"additional","affiliation":[{"name":"Neurology Service Internal Medicine Department Hospital Municipal S\u00e3o Jos\u00e9 Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Marques","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the Region of Joinville (UNIVILLE) Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Locks","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the Region of Joinville (UNIVILLE) Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francisca Moro","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the Region of Joinville (UNIVILLE) Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Heloisa Cabral","family":"Moro","sequence":"additional","affiliation":[{"name":"Neurology Service Internal Medicine Department Hospital Municipal S\u00e3o Jos\u00e9 Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Luiz","family":"Longo","sequence":"additional","affiliation":[{"name":"Neurology Service Internal Medicine Department Hospital Municipal S\u00e3o Jos\u00e9 Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Lucia","family":"Braatz","sequence":"additional","affiliation":[{"name":"Neurology Service Internal Medicine Department Hospital Municipal S\u00e3o Jos\u00e9 Joinville Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-243629"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0250-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa444"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26144"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26143"},{"key":"e_1_2_6_10_1","first-page":"e13426","article-title":"Neurological complications of COVID\u201019: Guillain\u2010Barre syndrome following Pfizer COVID\u201019 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