{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:17:36Z","timestamp":1776183456772,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Collagen cross\u2010linking has been reported to be effective in treating progressive keratoconus, and this study aims to evaluate the long\u2010term efficacy of this procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective longitudinal interventional study of patients with progressive keratoconus who underwent cross\u2010linking in a tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010five patients (51 eyes) who underwent cross\u2010linking with a mean follow\u2010up of 14.38\u2009\u00b1\u20099.36 months (range 6\u201348) were compared with a control group of 25 fellow eyes that did not undergo the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010linking was performed using 0.1% riboflavin (in 20% dextran <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>500) and ultraviolet <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> irradiation (370\u2009nm, 3\u2009m<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\/cm<jats:sup>2<\/jats:sup>, 30\u2009min).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Maximum keratometry in dioptres, log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> best spectacle\u2010corrected visual acuity, cylindrical power, manifest refraction spherical equivalent and central corneal thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of the treated group demonstrated a significant flattening of maximum keratometry by 0.96\u2009\u00b1\u20092.33 dioptres (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and a significant improvement in visual acuity by 0.05\u2009\u00b1\u20090.13 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). In the control group, maximum keratometry increased significantly by 0.43\u2009\u00b1\u20090.85 dioptres (<jats:italic>P<\/jats:italic>\u2009=\u20090.05), and visual acuity decreased by mean 0.05\u2009\u00b1\u20090.14 (<jats:italic>P<\/jats:italic>\u2009=\u20090.2). No statistical differences were noted regarding cylindrical power, spherical equivalent or corneal thickness in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results indicate that corneal collagen cross\u2010linking using riboflavin and ultraviolet <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> is effective as a therapeutic option in cases of progressive keratoconus by reducing the corneal curvature and by improving the visual acuity in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12035","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T13:13:53Z","timestamp":1352812433000},"page":"531-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prospective longitudinal study of corneal collagen cross\u2010linking in progressive 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