{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:07:05Z","timestamp":1789913225371,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sj\u00f6gren syndrome. We pathologically examined the lacrimal glands of autoimmune\u2010prone BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs<\/jats:styled-content> in the lacrimal fluid.<\/jats:p><\/jats:sec>Methods<\/jats:title>The lacrimal glands of the BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> and C57BL<\/jats:styled-content>\/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA<\/jats:styled-content> expression of water channels (A<\/jats:styled-content>qp3<\/jats:italic>, A<\/jats:styled-content>qp4<\/jats:italic> and A<\/jats:styled-content>qp5<\/jats:italic>). In addition, autoimmune model mice (MRL<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010lpr<\/jats:italic>\/lpr<\/jats:italic> and NZB<\/jats:styled-content>\/NZWF<\/jats:styled-content>1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNA<\/jats:styled-content>s (C<\/jats:styled-content>d68<\/jats:italic>, P<\/jats:styled-content>tprc<\/jats:italic> and C<\/jats:styled-content>d3e<\/jats:italic>) in the lacrimal fluids by polymerase chain reaction\u2010based methods.<\/jats:p><\/jats:sec>Results<\/jats:title>B\u2010cell predominant lymphocytic infiltrations and the destruction of acini were observed in the lacrimal glands of BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> mice. There was no significant difference in the quantity of lacrimal fluid between the BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> and C57BL<\/jats:styled-content>\/6 mice. In the BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> mice, A<\/jats:styled-content>qp3<\/jats:italic> expression increased significantly with the cell infiltration score, whereas expression of A<\/jats:styled-content>qp4<\/jats:italic> and A<\/jats:styled-content>qp5<\/jats:italic> tended to decrease. Aqp3<\/jats:italic> expression increased significantly with the cell infiltration score in BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> mice. Among inflammatory cell markers, C<\/jats:styled-content>d68<\/jats:italic> was more frequently detected in the lacrimal fluid of the BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic>, MRL<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010lpr<\/jats:italic>\/lpr<\/jats:italic> and NZB<\/jats:styled-content>\/NZWF<\/jats:styled-content>1 mice than in that of the C57BL<\/jats:styled-content>\/6 mice.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in lacrimal glands might be associated with the preservation of lacrimal fluid excretion in BXSB<\/jats:styled-content>\/MpJ<\/jats:styled-content>\u2010Y<\/jats:styled-content>aa<\/jats:italic> mice. The detection of inflammatory cell markers in lacrimal fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12083","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T04:14:20Z","timestamp":1361506460000},"page":"788-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["BXSB<\/scp>\/MpJ<\/scp>\u2010Y<\/scp>aa<\/i> mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs<\/scp> in the lacrimal fluid"],"prefix":"10.1111","volume":"41","author":[{"given":"Keigo","family":"Kosenda","sequence":"first","affiliation":[{"name":"Laboratory of Anatomy Department of Biomedical Sciences Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy 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