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Higher total energy delivered during TSCPC treatment was associated with an increased risk of hypotony: eyes that developed hypotony received a mean total energy of 192.5\u2009\u00b1\u200973.2 joules, compared to a mean of 152.9\u2009\u00b1\u200983.2 joules in hypotony\u2010free cases. The risk of sympathetic ophthalmia estimated from a review of the published literature and current series was one in 1512, or 0.07% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.03%\u20130.17%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Total laser energy is one of several risk factors that act in a sufficient component cause\u2010model to produce hypotony in an individual patient. The small sample size precluded inference for other individual putative risk factors but titrating laser energy may help decrease the occurrence of hypotony. 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