{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:04:01Z","timestamp":1787166241225,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n While\n L<\/jats:styled-content>\n eber hereditary optic neuropathy typically causes bilateral visual loss in the second through fourth decades, we highlight visual loss from\n L<\/jats:styled-content>\n eber hereditary optic neuropathy in older patients to characterize the clinical features of this cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective case series.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Patients seen between\n J<\/jats:styled-content>\n anuary 2003 and\n J<\/jats:styled-content>\n uly 2012 at\n B<\/jats:styled-content>\n aylor\n C<\/jats:styled-content>\n ollege of\n M<\/jats:styled-content>\n edicine and between\n A<\/jats:styled-content>\n pril 2010 and\n J<\/jats:styled-content>\n uly 2012 at The\n M<\/jats:styled-content>\n ethodist\n H<\/jats:styled-content>\n ospital in\n H<\/jats:styled-content>\n ouston,\n T<\/jats:styled-content>\n exas.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with visual loss from genetically confirmed\n L<\/jats:styled-content>\n eber hereditary optic neuropathy were identified via retrospective chart review.\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Clinical courses of patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Five patients with visual loss from genetically confirmed\n L<\/jats:styled-content>\n eber hereditary optic neuropathy were greater than 60\u2009years of age at the time of visual loss (range 62\u201370\u2009years, mean 66.4\u2009\u00b1\u20093.0).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This series reinforces the importance of including\n L<\/jats:styled-content>\n eber hereditary optic neuropathy in the differential diagnosis of patients of any age with optic neuropathy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ceo.12091","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T23:18:07Z","timestamp":1361488687000},"page":"690-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Late\u2010onset\n L<\/scp>\n eber hereditary optic neuropathy"],"prefix":"10.1111","volume":"41","author":[{"given":"Margaret L","family":"Pfeiffer","sequence":"first","affiliation":[{"name":"The University of Texas Medical School at Houston Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafiseh","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Methodist Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Foroozan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Methodist Hospital Houston Texas USA"},{"name":"Department of Ophthalmology Baylor College of Medicine Houston Texas USA"},{"name":"Department of Ophthalmology The University of Texas Medical Branch Galveston Texas USA"},{"name":"Departments of Ophthalmology, Neurology, and Neurosurgery Weill Cornell Medical College New York New York USA"},{"name":"Department of Ophthalmology The University of Iowa Hospitals and Clinic Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,11]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"481","article-title":"Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy","volume":"59","author":"Mackey DA","year":"1996","journal-title":"Am J Hum 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A case report","volume":"12","author":"DuBois LG","year":"1992","journal-title":"J Clin Neuroophthalmol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701388"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702729"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-005-0308-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0269-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr170"}],"container-title":["Clinical & Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:06:29Z","timestamp":1696352789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,11]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/ceo.12091"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12091","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,11]]},"assertion":[{"value":"2012-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}