{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:44:18Z","timestamp":1791805458954,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the efficacy of brinzolamide\u2010timolol fixed combination in intraocular pressure during the first 24\u2009h after uneventful phacoemulsification cataract surgery using <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>iscoat and Provisc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective randomized comparative case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Ninety\u2010two eyes of equal patients scheduled for phacoemulsification cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment group (52 eyes) received a drop of brinzolamide\u2010timolol fixed combination immediately after surgery. Control group (40 eyes) received no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Intraocular pressure preoperatively and at 6, 12 and 24\u2009h postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six hours after surgery the mean intraocular pressure decreased by 0.3\u2009\u00b1\u20092.95\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) in the treatment group and increased by 6.8\u2009\u00b1\u20092.78\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the control group. Twelve hours postoperatively, the mean intraocular pressure increased by 0.23\u2009\u00b1\u20093.49\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) in the treatment group and by 5.3\u2009\u00b1\u20093.26\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the control group. Twenty\u2010four hours after surgery, the mean intraocular pressure decreased by 1.76\u2009\u00b1\u20092.83\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) in the treatment group and in the control group increased by 1.4\u2009\u00b1\u20092.46\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The intraocular pressure in the treatment group was statistically significantly lower compared with the control group at 6, 12 and 24\u2009h postoperatively. None of the eyes in the treatment group had postoperative intraocular pressure elevation \u226510\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>; such an increase was recorded in 20% and 10% of control eyes at 6 and 12\u2009h after surgery, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single dose of brinzolamide\u2010timolol fixed combination after phacoemulsification cataract surgery prevented a significant intraocular pressure increase during the first 24\u2009h postoperatively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12092","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T04:18:06Z","timestamp":1361506686000},"page":"662-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brinzolamide\u2010timolol fixed combination for the prevention of intraocular pressure elevation after phacoemulsification"],"prefix":"10.1111","volume":"41","author":[{"given":"Constantine D","family":"Georgakopoulos","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Patras Medical School  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga E","family":"Makri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Patras Medical School  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Plotas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Patras Medical School  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pharmakakis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Patras Medical School  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)00994-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.12.1336"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020040262010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.02.064"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(83)90388-4"},{"key":"e_1_2_5_7_1","first-page":"315","article-title":"The effect of prophylactic acetazolamide on the intraocular pressure rise associated with Healon\u2010aided intraocular lens surgery","volume":"17","author":"Lewen R","year":"1985","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.12.050"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.07.024"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)00790-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00260-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.198"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00706-9"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01981-8"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00835.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.06.046"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(98)80172-7"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00364-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e3180587e0a"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S5573"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.08.046"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2000.00340.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.09.041"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1986.tb06929.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00641-6"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(96)80224-0"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(97)80254-4"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6441.347"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33110-6"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150552021"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1989.tb03340.x"}],"container-title":["Clinical &amp; 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