{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:17:29Z","timestamp":1773281849559,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the 6\u2010month efficacy and safety of the <jats:styled-content style=\"fixed-case\">iStent<\/jats:styled-content> microtrabecular bypass stent in patients with open\u2010angle glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective, uncontrolled, interventional case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Forty\u2010four eyes with open\u2010angle glaucoma were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All subjects underwent ab interno implantation of a single <jats:styled-content style=\"fixed-case\">iStent<\/jats:styled-content> together with (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200940) or without (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u20094) cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Patients were assessed at postoperative week 1, months 1 and 3, and quarterly, thereafter. Data collected included visual acuity, intraocular pressure measurement using <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>oldmann tonometry, number of glaucoma medications, and number and type of complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the sample was 76.8 years. The mean duration since glaucoma diagnosis was 5.3 years (standard deviation 2.9 years). The mean visual acuity was 0.53\u2009<jats:styled-content style=\"fixed-case\">logMAR<\/jats:styled-content> at baseline that improved to 0.23 at 6 months postoperatively. The mean baseline intraocular pressure was 21.1\u2009mm<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g, and this decreased significantly to 16.7\u2009mm<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g at 6 months (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01). The mean number of drops prescribed preoperatively was 2.3, which decreased to 0.6 at 6 months (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01). Sixty\u2010six per cent of patients were drop\u2010free at 6 months. One patient developed an hyphaema following surgery; no other adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">iStent<\/jats:styled-content> proved to be a safe and effective treatment for patients with open\u2010angle glaucoma over our 6\u2010month follow up period. Insertion resulted in a significant decrease in intraocular pressure as well as the number of topical antiglaucoma medications required for adequate intraocular pressure control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12098","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T16:36:13Z","timestamp":1362069373000},"page":"648-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Manchester <scp>iStent<\/scp> study: early results from a prospective <scp>UK<\/scp> case series"],"prefix":"10.1111","volume":"41","author":[{"given":"Ilesh","family":"Patel","sequence":"first","affiliation":[{"name":"Manchester Royal Eye Hospital Central Manchester University Hospitals NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A","family":"de Klerk","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital Central Manchester University Hospitals NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Au","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital Central Manchester University Hospitals NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960040789022"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(73)91145-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688909013902"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2001.152"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.3.297"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.11.1228"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000146360.07540.mL"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000212262.12112.42"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3972"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.07.035"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S2305"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00107-8"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000212294.31411.92"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3928\/1542-8877-19990101-09","article-title":"Intraocular pressure reduction following phacoemulsification cataract extraction with posterior chamber lens implantation in glaucoma patients","volume":"30","author":"Kim DD","year":"1999","journal-title":"Ophthalmic Surg Lasers"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.045"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.07.007"},{"key":"e_1_2_5_19_1","first-page":"321","article-title":"One\u2010year analysis of the iStent trabecular microbypass in secondary glaucoma","volume":"5","author":"Buchacra O","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-008-0062-6"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300218"},{"key":"e_1_2_5_22_1","first-page":"441","article-title":"A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma","volume":"6","author":"Garcia\u2010Feijoo J","year":"2012","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20110812-04"}],"container-title":["Clinical &amp; 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