{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:33:49Z","timestamp":1784396029271,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The result of primary open\u2010angle glaucoma is the loss of retinal ganglion cells. Transient receptor potential cation channel 6 is a pressure\u2010related channel that may function in the survival of retinal ganglion cells. The purpose of this study was to evaluate the expression levels of the transient receptor potential cation channel 6 gene in patients with primary open\u2010angle glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomization study at <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>hongshan <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>phthalmic <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>80 primary open\u2010angle glaucoma patients and 75 cataract patients recruited from <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>hongshan <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>phthalmic <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was extracted from the leukocytes of the peripheral blood collected. The levels of transient receptor potential cation channel 6\u2013messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> were determined by real\u2010time polymerase chain reaction. Related factors including age, intraocular pressure, optic cup\u2010to\u2010disc ratio and visual field defect were analysed accordingly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Clinical examination and the messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression level of the transient receptor potential cation channel 6 gene in the leukocytes of primary open\u2010angle glaucoma patients was two times higher when compared with control cataract patients. The gene expression level was also correlated with intraocular pressure and cup\u2010to\u2010disc ratio. Treatment with different anti\u2010glaucoma drugs did not affect the gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increasing expression levels of the transient receptor potential cation channel 6 gene in the blood accompanies chronic elevation of intraocular pressure in primary open\u2010angle glaucoma and may serve as a genetic biomarker for primary open\u2010angle glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12111","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T10:08:47Z","timestamp":1365502127000},"page":"753-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Increased expression of the transient receptor potential cation channel 6 gene in patients with primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"41","author":[{"given":"Shida","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M","family":"Laties","sequence":"additional","affiliation":[{"name":"Ophthalmology University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou 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