{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:56:14Z","timestamp":1781139374250,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:00:00Z","timestamp":1372982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the efficacy and safety of subconjunctival bevacizumab application as an adjuvant therapy for primary pterygium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This study was a clinical randomized trial performed at the Institute of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>phthalmology \u2018<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>onde de <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>alenciana\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Forty\u2010nine patients with primary pterygium were enrolled in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each primary pterygium patient was randomized after pterygium excision and a conjunctival autograft to receive either a single 2.5\u2009mg\/0.1\u2009m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> dose of subconjunctival bevacizumab immediately after surgery (group 1); a double 2.5\u2009mg\/0.1\u2009m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> injection of subconjunctival bevacizumab, one immediately after surgery and the second 15 days after surgery (group 2); or no injection (group 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Autoconjunctival graft presence or absence of ischaemia, necrosis, infection or detachment; surgical bed appearance; and pterygium recurrence at 1\u2010year follow\u2010up period were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine eyes of 49 patients were included. Sixteen patients were assigned to group 1, 17 to group 2 and 16 to group 3. Patients from groups 1 and 2 showed conjunctival autograft ischaemia at 24\u2009h postoperative (37.5% and 58.8%, respectively, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), which disappeared by the first postoperative month. No significant difference in the main outcome measures was found among single <jats:italic>versus<\/jats:italic> double\u2010dose of subconjunctival bevacizumab injection patients. At the end of the study, pterygium recurrences were observed only in group 3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single 2.5\u2009mg\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> subconjunctival bevacizumab injection in conjunction with primary pterygium surgery accomplishing a conjunctival autograft procedure is safe and well tolerated, and is capable of preventing pterygium recurrences when compared with a control group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12140","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T11:54:03Z","timestamp":1371556443000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Randomized, controlled trial of conjunctival autografting combined with subconjunctival bevacizumab for primary pterygium treatment: 1\u2010year follow\u2010up"],"prefix":"10.1111","volume":"42","author":[{"given":"Angel","family":"Nava\u2010Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Research Unit Institute of Ophthalmology Conde de Valenciana  Mexico City Mexico"},{"name":"Oculoplastics Department Institute of Ophthalmology Conde de Valenciana  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osiris","family":"Olvera\u2010Morales","sequence":"additional","affiliation":[{"name":"Oculoplastics Department Institute of Ophthalmology Conde de Valenciana  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Ramos\u2010Castellon","sequence":"additional","affiliation":[{"name":"Oculoplastics Department Institute of Ophthalmology Conde de Valenciana  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Garnica\u2010Hayashi","sequence":"additional","affiliation":[{"name":"Oculoplastics Department Institute of Ophthalmology Conde de Valenciana  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonathan","family":"Garfias","sequence":"additional","affiliation":[{"name":"Research Unit Institute of Ophthalmology Conde de Valenciana  Mexico City Mexico"},{"name":"Biochemistry Department Faculty of Medicine Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.151852"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.7.782"},{"key":"e_1_2_5_4_1","first-page":"2068","article-title":"Study of the expression of CD30 in pterygia compared to healthy conjunctivas","volume":"15","author":"Garfias Y","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63850-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200307000-00015"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1130"},{"key":"e_1_2_5_8_1","first-page":"153","article-title":"Pterygium: histological and immunohistochemical aspects","volume":"52","author":"Golu T","year":"2011","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702495"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.25.1.17.9959"},{"key":"e_1_2_5_11_1","first-page":"444","article-title":"Vascular endothelial growth factor (VEGF) \u2013 part 1: in physiology and pathophysiology","volume":"62","author":"Kajdaniuk D","year":"2011","journal-title":"Endokrynol Pol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041530317"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.2.11205"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2010.07.007"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.18"},{"key":"e_1_2_5_16_1","first-page":"179","article-title":"Subconjunctival bevacizumab injection in treatment of pterygium","volume":"49","author":"Besharati MR","year":"2011","journal-title":"Acta Med Iran"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31821c9b44"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182151e0e"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31820ca63f"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3126\/nepjoph.v3i1.4271","article-title":"Pterygia measurements are more accurate with anterior segment optical coherence tomography \u2013 a pilot study","volume":"3","author":"Welch MN","year":"2011","journal-title":"Nepal J Ophthalmol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30197-3"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.01.047"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000252980"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2010.0094"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.01.015"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318245c044"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.07.003"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701799101"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01399.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31817786ad"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181822615"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.32.2.65"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90706-4"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.7.433"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(89)90523-0"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)33831-9"},{"key":"e_1_2_5_37_1","first-page":"81","article-title":"Surgical management of recurrent pterygium by an operation of transposition","volume":"68","author":"Said A","year":"1975","journal-title":"Bull Ophthalmol Soc Egypt"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32667-4"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1991.tb00639.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3281a7ecbb"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7482.88"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12140","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:34:55Z","timestamp":1696300495000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,5]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/ceo.12140"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12140","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,5]]},"assertion":[{"value":"2012-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}