{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:23:09Z","timestamp":1791177789580,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study aims to investigate whether retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) abnormalities can be detected in patients with obstructive sleep apnoea\/hypopnoea syndrome with normally appearing optic disc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This is an observational case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>One hundred and eight consecutive patients with moderate or severe obstructive sleep apnoea\/hypopnoea syndrome (<jats:styled-content style=\"fixed-case\">OSAHS<\/jats:styled-content>) as determined by overnight polysomnography and normal looking discs and 108 age\u2010matched healthy controls were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients underwent <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> examinations by optical coherence tomography using fast retinal nerve fibre layer thickness scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The main outcome measure was <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate regression analysis results showed that the <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> was thinner for a patient with <jats:styled-content style=\"fixed-case\">OSAHS<\/jats:styled-content> than that of a normal control in the average by 4.20\u2009\u03bcm (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.003), in the superior quadrant by 4.83\u2009\u03bcm (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) and in the inferior quadrant by 5.19\u2009\u03bcm (<jats:italic>P<\/jats:italic>\u2009=\u20090.016). <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness did not correlate with the severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thinning was detected in normal\u2010looking discs of patients with advanced <jats:styled-content style=\"fixed-case\">OSAHS<\/jats:styled-content>, but the extent of this thinning did not correlate with the severity of the disease. Longitudinal follow\u2010up is needed to clarify whether <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thinning in <jats:styled-content style=\"fixed-case\">OSAHS<\/jats:styled-content> patients with normal clinically appearing optic nerves will eventually lead to glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12145","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T11:55:16Z","timestamp":1371556516000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome"],"prefix":"10.1111","volume":"42","author":[{"given":"Oded","family":"Sagiv","sequence":"first","affiliation":[{"name":"The Bruce Rappaport Faculty of Medicine The Technion \u2013 Israel Institute of Technology  Haifa 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