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In particular, the occurrence and progression of primary open\u2010angle glaucoma interact with the progression of <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>. Two hypotheses have been proposed to explain the association between the two disorders: the hypertension gene theory and the collagen\u2010related gene theory. <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content> and primary open\u2010angle glaucoma patients show similar collagen changes and hypersensitive responses to glucocorticoids. Consequently, these common features may hold key information regarding their underlying mechanisms. Advances in life sciences, such as molecular genetics, provide opportunities for clarifying their association at the molecular level. This article reviews available research on the association between these two disorders from the perspectives of epidemiology, clinical manifestation, diagnosis and pathogenic mechanisms.<\/jats:p>","DOI":"10.1111\/ceo.12158","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T09:22:45Z","timestamp":1373620965000},"page":"190-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Progress in understanding the association between high myopia and primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Fei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Eye &amp; ENT Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health PR China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Eye &amp; ENT Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health PR China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Eye &amp; ENT Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health PR China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2486","article-title":"Prevalence and risk factors for refractive errors in adult Chinese in Singapore","volume":"41","author":"Wong TY","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.495"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.02.042"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.8.1111"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.041210"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.11.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.303"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/301907"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.03.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060080068030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100070092031"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-009-0065-3"},{"key":"e_1_2_7_14_1","first-page":"61","article-title":"Glaucoma in myopic eyes","volume":"23","author":"Knapp A","year":"1925","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/0002-9394(66)92551-7","article-title":"High myopia and primary open\u2010angle glaucoma","volume":"62","author":"Podos SM","year":"1966","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.57.7.499"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040442015"},{"key":"e_1_2_7_18_1","first-page":"349","article-title":"High myopia and primary open\u2010angle glaucoma","volume":"22","author":"Wang RF","year":"1986","journal-title":"Chin J Ophthalmol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199030030-00009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090170088028"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90416-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790603.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.714"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01260-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00564-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.059"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00051-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.050"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.035"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.125"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2003.00158.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02169209"},{"key":"e_1_2_7_33_1","first-page":"312","article-title":"Axial length measurements and fundus changes of the myopic eye. 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