{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:41Z","timestamp":1791389321795,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>To clarify the effects of a single\u2010nucleotide polymorphism, rs4236601[A<\/jats:styled-content>] near caveolin 1 and 2, on primary open\u2010angle glaucoma (POAG<\/jats:styled-content>) risk.<\/jats:p><\/jats:sec>Design<\/jats:title>Meta\u2010analysis.<\/jats:p><\/jats:sec>Participants<\/jats:title>A total of 5774 patients and 40\u2009598 controls from previously reported case\u2013control studies were included.<\/jats:p><\/jats:sec>Methods<\/jats:title>A comprehensive literature search was performed for studies published up to A<\/jats:styled-content>pril 2013. Summary odds ratios (OR<\/jats:styled-content>s) and 95% confidence intervals (CI<\/jats:styled-content>) were calculated, employing random\u2010 or fixed\u2010effects models according to between\u2010study heterogeneity. Publication bias of the literature articles was evaluated using funnel plots and E<\/jats:styled-content>gger's test.<\/jats:p><\/jats:sec>Main Outcome Measures<\/jats:title>OR<\/jats:styled-content> for the effects of rs4236601[A<\/jats:styled-content>] on POAG<\/jats:styled-content> risk.<\/jats:p><\/jats:sec>Results<\/jats:title>Five eligible studies were included in this meta\u2010analysis. Overall, the association between rs4236601[A<\/jats:styled-content>] and risk for POAG<\/jats:styled-content> was statistically significant (OR<\/jats:styled-content>\u2009=\u20091.23, 95% CI<\/jats:styled-content> 1.12\u20131.34; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001). Stratified analyses showed that the association between rs4236601[A<\/jats:styled-content>] and POAG<\/jats:styled-content> risk was statistically significant in C<\/jats:styled-content>aucasians (OR<\/jats:styled-content>\u2009=\u20091.25, 95% CI<\/jats:styled-content> 1.18\u20131.33; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001) and A<\/jats:styled-content>sians (OR<\/jats:styled-content>\u2009=\u20093.33, 95% CI<\/jats:styled-content> 1.56\u20137.08; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.003) but not in A<\/jats:styled-content>fricans. Increased risks were found in age\u2010 and sex\u2010matched studies (OR<\/jats:styled-content>\u2009=\u20091.26, 95% CI<\/jats:styled-content> 1.14\u20131.40; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001), but no statistically significant risk was found in unmatched studies.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This meta\u2010analysis suggests that rs4236601[A<\/jats:styled-content>] is associated with increased risk for POAG<\/jats:styled-content> in C<\/jats:styled-content>aucasian and A<\/jats:styled-content>sian populations. However, well\u2010designed gene\u2013environment interaction studies and studies including more ethnic groups are required in further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12201","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T12:46:32Z","timestamp":1378212392000},"page":"515-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of single\u2010nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open\u2010angle glaucoma: a meta\u2010analysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Wenbin","family":"Huang","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804630"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0299"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713680903548970"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.11.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.6.080604.162209"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.08.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046632"},{"key":"e_1_2_5_10_1","first-page":"R369","article-title":"Meta\u2010analysis of association between optineurin gene and primary open\u2010angle 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