{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:46Z","timestamp":1787014006035,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n A major disadvantage of photorefractive keratectomy is postoperative pain and discomfort. This study aims to evaluate whether topical diclofenac 0.1% therapy adds any extra benefit to systemic diclofenac in controlling pain after photorefractive keratectomy.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Prospective randomized, double\u2010masked clinical trial applied in the\n K<\/jats:styled-content>\n hatam\u2010al\u2010\n A<\/jats:styled-content>\n nbia\n E<\/jats:styled-content>\n ye\n H<\/jats:styled-content>\n ospital,\n M<\/jats:styled-content>\n ashhad\n U<\/jats:styled-content>\n niversity of\n M<\/jats:styled-content>\n edical\n S<\/jats:styled-content>\n ciences,\n M<\/jats:styled-content>\n ashhad,\n I<\/jats:styled-content>\n ran.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Sixty\u2010eight individuals (age range, 18\u201335 years) having bilateral photorefractive keratectomy for myopic correction with or without astigmatism.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All patients received 100\u2009mg of extended\u2010release oral diclofenac two times (12\u2010h interval) before photorefractive keratectomy surgery. Postoperatively, patients were randomized into the case and control groups. Case group was administered the diclofenac 0.1% drop, one drop 2\u2009h preoperatively and four times daily postoperatively for 3 days, whereas the control group was given artificial tears instead.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Pain level, photophobia and functional activity were evaluated by the patient after operation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two days after surgery, no statistically significant difference in pain level was noted between both groups. In addition, photophobia and functional activity was not different between the case and control groups. Eyelid oedema and conjunctival injection levels were significantly higher in the control group (\n \n P<\/jats:italic>\n <\/jats:styled-content>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Administration of topical diclofenac to a standardized postoperative pain regime did not alleviate post\u2010photorefractive keratectomy pain, although it is effective in local signs like eyelid oedema and conjunctival injection. It can be concluded that oral diclofenac is sufficient in the management of post\u2010photorefractive keratectomy pain and addition of the topical diclofenac is unnecessary.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ceo.12343","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T03:53:09Z","timestamp":1396583589000},"page":"810-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of topical diclofenac on postoperative photorefractive keratectomy pain: a randomized, controlled trial"],"prefix":"10.1111","volume":"42","author":[{"given":"Alireza","family":"Eslampoor","sequence":"first","affiliation":[{"name":"Cornea Research Center, Faculty of Medicine Mashhad University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asieh","family":"Ehsaei","sequence":"additional","affiliation":[{"name":"Refractive Errors Research Center, 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