{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:11:33Z","timestamp":1762161093006},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Comparative, experimental study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Samples<\/jats:title><jats:p>Twenty eight eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight male <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> group underwent trabeculectomy, and a sponge soaked in 0.4\u2009mg\/mL mitomycin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> was applied intraoperatively to the scleral surgical site for 3\u2009min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2\u2009mg\/0.1\u2009mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Mean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor\u2010\u03b2, fibroblast growth factor\u2010\u03b2, and platelet derived growth factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The mean cell numbers and immunostaining intensities in the mitomycin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> group and trastuzumab group were statistically significantly lower than those of the sham group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) while mean cell numbers and immunostaining intensities in the mitomycin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> group and trastuzumab group were similar (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12359","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T11:36:51Z","timestamp":1399462611000},"page":"67-76","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of trastuzumab on wound healing in experimental glaucoma surgery"],"prefix":"10.1111","volume":"43","author":[{"given":"Burak","family":"Turgut","sequence":"first","affiliation":[{"name":"Department of Ophthalmology School of Medicine F\u0131rat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology School of Medicine F\u0131rat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet M","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine F\u0131rat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagehan","family":"Bilir Can","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinics Elaz\u0131\u011f Education and Training Hospital  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology School of Medicine F\u0131rat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2012.02.003"},{"key":"e_1_2_5_3_1","first-page":"1","volume-title":"Ophthalmology","author":"Fellman RL","year":"1999"},{"key":"e_1_2_5_4_1","first-page":"861","article-title":"Update of adjunctive antimetabolities in glaucoma surgery","volume":"4","author":"Reder JE","year":"1991","journal-title":"Ophthalmol Clin North Am"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9483l"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32834ff401"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.01.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-200404420-00007"},{"key":"e_1_2_5_9_1","first-page":"2136","article-title":"Effects of mithramycin, mitomycin C, daunorubicin, and bleomycin on human subconjunctival fibroblast attachment and proliferation","volume":"31","author":"Lee DA","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1990.6.175"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130095036"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140151007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30639-8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl475"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi905"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64253-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/416279b"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209685"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.09.022"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(68)91288-9"},{"key":"e_1_2_5_21_1","first-page":"84","article-title":"Clinicopathologic correlation in eyes with failed fistulizing surgery","volume":"103","author":"Hitchings RA","year":"1983","journal-title":"Trans Ophthalmol Soc U K"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e3181924d55"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1994.44"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00946945"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170100275"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210001000203"},{"key":"e_1_2_5_27_1","first-page":"273","article-title":"Mediation of post\u2010surgical wound healing by macrophages","volume":"266","author":"Bryant SM","year":"1988","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803243181205"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.6.466"},{"key":"e_1_2_5_30_1","first-page":"131","article-title":"Macrophages, wound repair and angiogenesis","volume":"266","author":"Leibovich SJ","year":"1988","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.20.1"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(00)00135-1"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00007-5"},{"key":"e_1_2_5_34_1","first-page":"2225","article-title":"Human anti\u2010transforming growth factor\u2010beta 2 antibody: a new glaucoma antiscarring agent","volume":"40","author":"Cordeiro MF","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_35_1","first-page":"1975","article-title":"Transforming growth factor\u2010beta1, \u2010beta2, and \u2010beta3 in vivo: effects on normal and mitomycin C\u2010modulated conjunctival scarring","volume":"40","author":"Cordeiro MF","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1995.01430090085025"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90560-X"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)02056-O"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1994.43"},{"key":"e_1_2_5_40_1","first-page":"1998","article-title":"Single exposures to antiproliferatives: long\u2010term effects on ocular fibroblast wound\u2010healing behavior","volume":"38","author":"Occleston NL","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2002.2066"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.27.2.35.15456"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1121"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32456-9"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)32025-1"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.01.041"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0549"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(01)90276-3"},{"key":"e_1_2_5_49_1","unstructured":"Herceptin product monograph Genentech (a Roche group) 2013. Accessed 13 Jun 2014. Available fromhttp:\/\/www.rochecanada.com\/fmfiles\/re7234008\/Research\/ClinicalTrialsForms\/Products\/ConsumerInformation\/MonographsandPublicAdvisories\/Herceptin\/Herceptin_PM_E.pdf"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.601840"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12359","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:26:49Z","timestamp":1696336009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,19]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/ceo.12359"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12359","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,19]]},"assertion":[{"value":"2014-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}