{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:38:09Z","timestamp":1790645889556,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the possible association of the rs2165241 polymorphism (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2009&gt;\u2009<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\"><jats:italic>LOXL1<\/jats:italic><\/jats:styled-content> gene with the risk of primary open\u2010angle glaucoma in a <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>editerranean population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The analysis of genetic polymorphisms was performed by standard <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an allelic discrimination technique, using a 7900<jats:styled-content style=\"fixed-case\">HT S<\/jats:styled-content>equence <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>etection <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pplied <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iosystems).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a recessive genetic model, the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> allele of the rs2165241 polymorphism was significantly associated with the risk of primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>: odds ratios\u2009=\u20092.19, 95% confidence interval\u2009=\u2009[1.33\u20133.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>: odds ratios\u2009=\u20092.07, 95% confidence interval\u2009=\u2009[1.20\u20133.57]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This polymorphism seems to be associated with high risk for primary open\u2010angle glaucoma in a <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>editerranean population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12367","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T13:51:14Z","timestamp":1401803474000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic polymorphism related to exfoliative glaucoma is also associated with primary open\u2010angle glaucoma risk"],"prefix":"10.1111","volume":"43","author":[{"given":"Vicente","family":"Zanon\u2010Moreno","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health School of Medicine University of Valencia  Valencia Spain"},{"name":"Ophthalmology Research Unit \u2018Santiago Grisolia\u2019  Valencia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zanon\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health School of Medicine University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ortega\u2010Azorin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public 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