{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:01:18Z","timestamp":1771592478849,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T00:00:00Z","timestamp":1411171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue contre le cancer","doi-asserted-by":"crossref","award":["000"],"award-info":[{"award-number":["000"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Orbital rhabdomyosarcoma (<jats:styled-content style=\"fixed-case\">ORMS<\/jats:styled-content>) is associated with an excellent survival rate greater than 85%, and is considered to be a favourable site for this tumour. Treatment is based on combination chemotherapy together with best local therapy, sometimes surgery but more often radiation therapy. Local therapy is associated with frequent and potentially severe late sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective hospital single\u2010centre analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Eighty\u2010two patients treated in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nstitut <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>urie, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To define long\u2010term status of survivors after localized <jats:styled-content style=\"fixed-case\">ORMS<\/jats:styled-content>, patients treated between 1975 and 2010 were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Clinical structural and functional orbital, and general sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at diagnosis was 6 years (range: 8 months\u201319 years), and median follow up was 8.5 years (range: 7 months\u201324 years). The 5\u2010year globe conservation rate was 90.4%. Ophthalmic dysfunction was present in 79% of patients. Impaired visual acuity (<jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>), was present in 62% of patients; 38% of them had severe visual disability with <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>\u2009&lt;\u20096\/60. Late effects on orbitofacial structure were present in 39.8% of patients. Ocular or palpebral sequelae were present in 79% of survivors, mainly cataract (42%), ocular surface lesions such as keratoconjunctivitis (40%) and eyelid abnormalities (29%). General late effects were rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that ocular and orbital late effects are frequent after treatment of <jats:styled-content style=\"fixed-case\">ORMS<\/jats:styled-content>, indicating the need for systematic long\u2010term ophthalmologic follow up of these patients. 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