{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:10:52Z","timestamp":1791198652909,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the chorioretinal thickness changes using spectral\u2010domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD\u2010OCT<\/jats:styled-content>) and to evaluate the association between these structural changes and cognitive impairment in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, cross\u2010sectional study<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010one eyes of 31 consecutive patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and 30 eyes of 30 cognitively healthy age\u2010matched control subjects were recruited<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SD\u2010OCT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RTV<\/jats:styled-content>ue\u2010100) was used to measure the macular ganglion cell complex thickness (<jats:styled-content style=\"fixed-case\">mGCC<\/jats:styled-content>), outer retinal thickness (<jats:styled-content style=\"fixed-case\">ORL<\/jats:styled-content>), and the choroidal thickness (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>). Cognitive function was evaluated by <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tate examination (<jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>) on the same day of the optical examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Chorioretinal thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">mGCC<\/jats:styled-content> average, <jats:styled-content style=\"fixed-case\">mGCC<\/jats:styled-content> superior and <jats:styled-content style=\"fixed-case\">mGCC<\/jats:styled-content> inferior thicknesses of the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group were significantly thinner than those of the controls (all, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No significant difference was found in the <jats:styled-content style=\"fixed-case\">ORL<\/jats:styled-content> thickness measurements between the two groups. Compared with control subjects, the <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> measurements at all regions were significantly thinner in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> than controls except <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> measurement at 3.0\u2009mm temporal to the fovea (<jats:italic>P<\/jats:italic>\u2009=\u20090.067). Significant correlations between the <jats:styled-content style=\"fixed-case\">mGCC<\/jats:styled-content> thickness measurements of the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group and <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content> scores were observed. There was no significant correlation between the <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content> scores and the <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> measurements (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> had chorioretinal structural alterations. Retinal structural alterations were seen only in the inner layers. The reduction in <jats:styled-content style=\"fixed-case\">mGCC<\/jats:styled-content> thickness parameters were related to the severity of cognitive impairment in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12386","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T04:12:37Z","timestamp":1404447157000},"page":"145-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Evaluation of the chorioretinal thickness changes in <scp>A<\/scp>lzheimer's disease using spectral\u2010domain optical coherence tomography"],"prefix":"10.1111","volume":"43","author":[{"given":"Hasan Ali","family":"Bayhan","sequence":"first","affiliation":[{"name":"Ophthalmology Department Bozok University Faculty of Medicine  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seray","family":"Aslan Bayhan","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Bozok University Faculty of Medicine  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman","family":"Celikbilek","sequence":"additional","affiliation":[{"name":"Neurology Department Bozok University Faculty of Medicine  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Tan\u0131k","sequence":"additional","affiliation":[{"name":"Neurology Department Bozok University Faculty of Medicine  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"G\u00fcrdal","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Bozok University Faculty of Medicine  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.12.024"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2013.10.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290110"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb00187.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608213150804"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1029"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wno.0000204645.56873.26"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00321132"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101908"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10827"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3182934af6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00683-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1849"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_5_17_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM\u2010IV)","year":"1994"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.025"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90653-7"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb00188.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512802455340"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260207"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0476-x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0287-z"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.020"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-200606000-00010"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720510790274491"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2011.02.014"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.02.090"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12046"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00010-3"},{"key":"e_1_2_5_33_1","first-page":"2857","article-title":"Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan RS","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1379.004"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00125-1"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.06.009"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12888"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws243"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:52:49Z","timestamp":1696294369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,15]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/ceo.12386"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12386","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,15]]},"assertion":[{"value":"2014-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}