{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T21:38:37Z","timestamp":1780781917108,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To report the treatment outcomes of mycotic keratitis with collagen cross\u2010linking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with smear\u2010positive moderate mycotic keratitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2010file analysis was performed to identify cases of moderate mycotic keratitis treated with and without additional collagen cross\u2010linking, in addition to intensive topical antifungal therapy. Patients in which collagen cross\u2010linking was performed on the day of presentation (group 1) were compared with patients who received medical treatment alone in the form of 5% natamycin eye drops (group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The primary outcome measure was the time taken for resolution of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 41 cases were included for analysis (group 1, 20 cases; group 2, 21 cases). Mean age of the patients was comparable in both groups (46.5\u2009\u00b1\u200917.01<jats:italic>vs.<\/jats:italic>41.2\u2009\u00b1\u200920.7 years;<jats:italic>P<\/jats:italic>\u2009=\u20090.36). Average infiltrate size was 16.35\u2009\u00b1\u20096.8\u2009mm<jats:sup>2<\/jats:sup>in group 1 and 17.09\u2009\u00b1\u20097.4\u2009mm<jats:sup>2<\/jats:sup>in group 2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.83). Overall,<jats:italic>Aspergillus<\/jats:italic>was the most commonly isolated organism (<jats:italic>n<\/jats:italic>\u2009=\u20094 group 1;<jats:italic>n<\/jats:italic>\u2009=\u20096 group 2). Resolution of infection was observed in 18 cases (90%) in group 1 and 18 (85.71%) cases in group 2. The average healing time was 30.85\u2009\u00b1\u200926.6 days in group 1, while it was 31.28\u2009\u00b1\u200919.97 days in group 2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.94). Final best\u2010corrected visual acuity in group 1 was 1.13\u2009\u00b1\u20090.55 and 1.25\u2009\u00b1\u20090.46 in group 2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.46). A tectonic keratoplasty was performed in two cases in group 1 and three cases in group 2 (<jats:italic>P<\/jats:italic>\u2009=\u20091.00).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study, additional collagen cross\u2010linking treatment did not have any advantage over medical management in cases with moderate mycotic keratitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12399","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T02:14:15Z","timestamp":1406600055000},"page":"103-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Evaluation of corneal collagen cross\u2010linking as an additional therapy in mycotic keratitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Rasik B","family":"Vajpayee","sequence":"first","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi Orissa India"},{"name":"Centre for Eye Research Australia University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shah N","family":"Shafi","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi Orissa India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla K","family":"Maharana","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi Orissa India"},{"name":"LV Prasad Eye Institute Bhubaneswar Orissa India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Sharma","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi Orissa India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Jhanji","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia University of Melbourne Melbourne Victoria Australia"},{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"214","article-title":"Corneal blindness: a global perspective","volume":"79","author":"Whitcher JP","year":"2001","journal-title":"Bull World Health Organ"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.11.965"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200405000-00009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200408000-00008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S10819"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.023"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S24532"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302518"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20120921-06"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181d2de91"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(81)34943-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042126"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(65)90182-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1423-0410.2000.tb00065.x","article-title":"The use of riboflavin for inactivation of pathogens in blood products","volume":"78","author":"Goodrich RP","year":"2000","journal-title":"Vox Sang"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490513182"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/406850"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200401000-00008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318254a41b"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.12.026"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e3181be722e"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318199fa77"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180334f78"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1592"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4013"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.1497"}],"container-title":["Clinical &amp; 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