{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:26:56Z","timestamp":1791962816579,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increase in intraocular pressure is a recognized complication of corticosteroid treatment via intravitreal or periocular injections for treatment of a range of conditions including macular oedema and retinal neovascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This surveillance study was designed to determine the incidence and nature of severe intraocular pressure elevation as a complication of intravitreal or periocular corticosteroid injections in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Seventeen cases meeting the defined criteria of severe intraocular pressure elevation, above 35\u2009mmHg, following an intravitreal or periocular corticosteroid injection were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over an 18\u2010month period, ophthalmologists were invited to report cases to the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>phthalmic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urveillance <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nit. After reporting, further demographic and clinical information was sought via a follow\u2010up questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Intraocular pressure elevation above 35\u2009mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up questionnaires were received for 20 cases of 34 initially reported to the unit. Seventeen met the defined criteria. Triamcinolone acetonide was used in all 17 cases, with 16 delivered as a 4\u2010mg intravitreal injection. There was an absence of identified underlying risk factors in the majority of cases with personal history of glaucoma in 2 of 17 cases. No cases reported a positive family history of glaucoma. Trabeculectomy was performed in 8 of 17 patients (47%) for intraocular pressure management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe intraocular pressure elevation following intravitreal or periocular corticosteroid injection can occur in the absence of risk factors such as personal and family history of glaucoma. The severe intraocular pressure elevation may ultimately require trabeculectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12433","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T16:25:15Z","timestamp":1410452715000},"page":"234-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severe intraocular pressure response to periocular or intravitreal steroid treatment in <scp>A<\/scp>ustralia and <scp>N<\/scp>ew <scp>Z<\/scp>ealand: data from the <scp>A<\/scp>ustralian and <scp>N<\/scp>ew <scp>Z<\/scp>ealand <scp>O<\/scp>phthalmic <scp>S<\/scp>urveillance <scp>U<\/scp>nit"],"prefix":"10.1111","volume":"43","author":[{"given":"Jude T","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn","family":"Ridge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew JR","family":"White","sequence":"additional","affiliation":[{"name":"Save Sight and Westmead Millennium Institutes University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Discipline of Ophthalmology University of Sydney  Sydney New South Wales Australia"},{"name":"Glaucoma Unit Sydney Eye Hospital  Sydney New South Wales Australia"},{"name":"Eye Associates  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology St John of God Hospital  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard AD","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,8]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1075","article-title":"Corticosteroid glaucoma","volume":"9","author":"Francois J","year":"1977","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1969.00990010790006"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.3.336"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01969-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X187946"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.042"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702416"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01492.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.090340"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.185"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.306"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328630"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701895"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700233"}],"container-title":["Clinical &amp; 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