{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:20:18Z","timestamp":1777526418258,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The survival rates for patients diagnosed with uveal melanoma in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia are unknown. Few long\u2010term studies of uveal melanoma are available, and it is unclear whether their results are applicable to the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients diagnosed with uveal melanoma between 1981 and 2005 in <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred eight cases were included. Relative survival and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox regression were performed. Variables tested for their predictive ability included patient age and sex, tumour\u2010specific variables, and treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>All\u2010cause survival rates and relative survival rates of patients with diagnosed uveal melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative survival rates for the entire cohort were 88.2%, 81.4% and 71.4% at 3, 5 and 10 years, respectively. Predictors of worse survival included mixed\u2010cell tumour morphology (hazard ratio [HR]\u2009=\u20092.1; <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.002), tumour location at the ciliary body (HR\u2009=\u20091.7; <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.029) and tumour apical height more than 5\u2009mm (HR 1.9, <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.026). Of all patients who underwent enucleation, those diagnosed in 1998\u20132005 died twice as fast (HR\u2009=\u20092.3; <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.004). In the 17 patients with metastasis, the median survival time from date of diagnosis of metastasis was 3.1 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These survival estimates are comparable to those reported for the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>, and more optimistic than those reported for most <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean\u2010based studies. Tumour apical height, tumour site, tumour morphology and having an enucleation in certain calendar periods of diagnosis were independent predictors of survival. Survival prognosis for patients with diagnosed metastatic uveal melanoma is very poor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12490","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T06:53:19Z","timestamp":1420008799000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Survival from uveal melanoma in <scp>W<\/scp>estern <scp>A<\/scp>ustralia 1981\u20132005"],"prefix":"10.1111","volume":"43","author":[{"given":"Avenell L","family":"Chew","sequence":"first","affiliation":[{"name":"Lions Eye Institute Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Spilsbury","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research Curtin University  Curtin Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy W","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Department of Opthalmology Royal Perth Hospital and Lions Eye Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ohc.2004.07.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11057"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00078-2"},{"key":"e_1_2_6_5_1","first-page":"2579","article-title":"Incidence of uveal melanoma in Sweden from 1960 to 1998","volume":"43","author":"Bergman L","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400206"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.032"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(88)90173-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00077-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.040"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931001)72:7<2219::AID-CNCR2820720725>3.0.CO;2-J"},{"key":"e_1_2_6_12_1","first-page":"131","article-title":"Malignant melanotic tumors of the eye: a study of histologic types in 111 cases","volume":"36","author":"Callender G","year":"1931","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_6_13_1","first-page":"101","article-title":"The relative survival rate: a statistical methodology","volume":"6","author":"Ederer F","year":"1961","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2011.01640.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286580600553330"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0538"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.10.1413"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286580600977281"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70179-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(96)80024-5"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30911-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0081"},{"key":"e_1_2_6_24_1","article-title":"The DecisionDx\u2010UM gene expression profile test provides risk stratification and individualized patient care in uveal melanoma","volume":"5","author":"Harbour JW","year":"2013","journal-title":"PLoS Curr"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-727-3_22"}],"container-title":["Clinical &amp; 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