{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:50:05Z","timestamp":1773697805165,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Single nucleotide polymorphisms (SNP<\/jats:styled-content>s) rs<\/jats:styled-content>11024102 in PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic> and rs<\/jats:styled-content>3753841 in COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic> were identified to be associated with primary angle closure glaucoma (PACG<\/jats:styled-content>) by a recent large genome\u2010wide association study. This present study is to evaluate the association of PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic>\u2005rs<\/jats:styled-content>11024102 and COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic>\u2005rs<\/jats:styled-content>3753841 with PACG<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design<\/jats:title>A systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec>Participants<\/jats:title>A total of 25\u2009271 subjects (4895 PACG<\/jats:styled-content> patients and 20\u2009376 controls) in different ethnicities were tested for PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic>\u2005rs<\/jats:styled-content>11024102 and COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic> rs3753841.<\/jats:p><\/jats:sec>Methods<\/jats:title>A comprehensive literature search was conducted on studies published up to J<\/jats:styled-content>uly 2014. Summary odds ratios (OR<\/jats:styled-content>s) and 95% confidence intervals were analysed. Publication bias of the included articles was evaluated using funnel plots and E<\/jats:styled-content>gger's test.<\/jats:p><\/jats:sec>Main Outcome Measures<\/jats:title>OR<\/jats:styled-content> for the effects of PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic>\u2005rs<\/jats:styled-content>11024102 and COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic>\u2005rs<\/jats:styled-content>3753841 on PACG<\/jats:styled-content> risk.<\/jats:p><\/jats:sec>Results<\/jats:title>Four eligible articles were included in this study for meta\u2010analysis. The overall result showed that SNP<\/jats:styled-content>s rs<\/jats:styled-content>11024102 and rs<\/jats:styled-content>3753841 were statistically associated with PACG<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.001) in fixed\u2010effects model. Stratified analyses showed that the association of PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic>\u2005rs<\/jats:styled-content>11024102 and COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic>\u2005rs<\/jats:styled-content>3753841 with PACG<\/jats:styled-content> was statistically significant in A<\/jats:styled-content>sian population (including S<\/jats:styled-content>outh I<\/jats:styled-content>ndian cohort) (P<\/jats:italic>\u2009<\u20090.001). In C<\/jats:styled-content>aucasian population, significant association of COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic>\u2005rs<\/jats:styled-content>3753841 with PACG<\/jats:styled-content> was detected (P<\/jats:italic>\u2009=\u20090.004), but PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic>\u2005rs<\/jats:styled-content>11024102 did not show any association with PACG<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.140).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This meta\u2010analysis suggests that PLEKHA<\/jats:italic><\/jats:styled-content>7<\/jats:italic>\u2005rs<\/jats:styled-content>11024102 is associated with PACG<\/jats:styled-content> in A<\/jats:styled-content>sian population and COL<\/jats:italic><\/jats:styled-content>11<\/jats:italic>A<\/jats:italic><\/jats:styled-content>1<\/jats:italic>\u2005rs<\/jats:styled-content>3753841 has a genetic association with the development of PACG<\/jats:styled-content> both in C<\/jats:styled-content>aucasian and A<\/jats:styled-content>sian populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12516","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T04:05:50Z","timestamp":1425269150000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic associations in PLEKHA<\/i><\/scp>7<\/i> and COL<\/i><\/scp>11<\/i>A<\/i><\/scp>1<\/i> with primary angle closure glaucoma: a meta\u2010analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Ping","family":"Shuai","sequence":"first","affiliation":[{"name":"Sichuan Provincial Key Laboratory for Disease Gene Study Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital Chengdu Sichuan China"},{"name":"Health Management Center Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital Chengdu Sichuan China"},{"name":"School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"},{"name":"Department of Ophthalmology Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulan","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Key Laboratory for Disease Gene Study Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital Chengdu Sichuan 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