{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:31:45Z","timestamp":1780702305240,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21791725"],"award-info":[{"award-number":["21791725"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["20591038"],"award-info":[{"award-number":["20591038"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has recently become clear that glaucoma is not only an ocular disease, but involves central visual pathways as well. The purpose of this study was to examine functional and structural alterations in the brains of glaucoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study in a hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 32 glaucoma patients and 19 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants underwent positron emission tomography with <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u2010fluorodeoxyglucose, diffusion\u2010tensor magnetic resonance imaging, and the 30\u20102 program of the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>umphrey <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>isual <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ield <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nalyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Fractional anisotropy values of the optic radiation were compared between the two groups by defining regions of interests. Cerebral glucose metabolism was compared using statistical parametric mapping software. The correlation coefficients were calculated between the average of the total deviation of hemivisual fields of both eyes, fractional anisotropy values of the contralateral optic radiation and glucose metabolism in the contralateral striate cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fractional anisotropy values in the bilateral optic radiations were significantly lower in patients with glaucoma. A significant glucose hypometabolism in the bilateral striate cortex was also observed in the glaucoma group. Regression analyses for glaucoma patients demonstrated that the average of the total deviation of hemivisual fields significantly correlated with both fractional anisotropy value of the contralateral optic radiation and glucose metabolism in the contralateral striate cortex. Moreover, there were significant correlations between fractional anisotropy values of the optic radiation and ipsilateral striatal glucose metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed structural alterations in the bilateral optic radiations and glucose hypometabolism in the bilateral striate cortex of glaucoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12543","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T07:47:31Z","timestamp":1429688851000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cerebral glucose metabolism in the striate cortex positively correlates with fractional anisotropy values of the optic radiation in patients with glaucoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Hideki","family":"Murai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science Graduate School Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihisa","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Graduate School Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kiyosawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Graduate School Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Kiyosawa Eye Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya M","family":"Tokumaru","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Ishiwata","sequence":"additional","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00014-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.138172"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5682"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081240"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.01.014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/849632"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp119"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(89)90009-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.10.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4834"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.238"},{"key":"e_1_2_5_13_1","first-page":"121","volume-title":"Automated Static Perimetry","author":"Anderson DR","year":"1999"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-013-0233-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.081"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.122"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0468-5"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.88"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19970701-16"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.03.013"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.585759"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(06)80027-X"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200304000-00008"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.004"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)01132-1"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-03-00641.1991"},{"key":"e_1_2_5_27_1","first-page":"251","article-title":"Acquired color vision and visual field defects in patients with ocular hypertension and early glaucoma","volume":"3","author":"Papaconstantinou D","year":"2009","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1406"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0246"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-003-0040-0"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12543","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:11:40Z","timestamp":1695557500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/ceo.12543"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12543","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]},"assertion":[{"value":"2014-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}