{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:26:37Z","timestamp":1787066797299,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,16]],"date-time":"2015-08-16T00:00:00Z","timestamp":1439683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sensimed AG"},{"name":"Alcon Laboratories, Inc."},{"DOI":"10.13039\/100005616","name":"Allergan, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005616","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002806","name":"Carl Zeiss Meditec, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002806","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pfizer, Inc."},{"name":"Reichert, Inc."},{"DOI":"10.13039\/501100002806","name":"Carl Zeiss Meditec","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002806","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heidelberg Engineering GmbH"},{"name":"Nidek"},{"name":"Optovue"},{"name":"Topcon Medical Systems"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The aim of this article was to study the circadian intraocular pressure (\n IOP<\/jats:styled-content>\n )\u2010related effects of ocular hypotensive medications using a contact lens sensor (\n CLS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n This is a university\u2010based prospective, randomized, crossover trial.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n A total of 23 patients with primary open\u2010angle glaucoma participated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients underwent ambulatory recording of\n IOP<\/jats:styled-content>\n \u2010related patterns for 24\u2009h in one eye during 3 monthly sessions using a\n CLS<\/jats:styled-content>\n . Patients were untreated in session 1 (\n S1<\/jats:styled-content>\n ), were randomized to one of four classes of glaucoma drops for\n S2<\/jats:styled-content>\n and had a prostaglandin analogue add\u2010on for\n S3<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n \n Changes in\n IOP<\/jats:styled-content>\n \u2010related patterns were defined using (i) slopes from wake\/sitting to sleep\/supine; (ii) cosinor rhythmometry modelling; and (iii) area under receiver operating curve (\n AUC<\/jats:styled-content>\n ) of sleep period.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean patient age was 63.8\u2009\u00b1\u200911.8 years. Positive linear slopes were seen from wake\/sitting to sleep\/supine at\n S1<\/jats:styled-content>\n (17.1\u2009\u00b1\u200914.2\u2009\n mVeq<\/jats:styled-content>\n \/h) and\n S2<\/jats:styled-content>\n (5.5\u2009\u00b1\u200923.9\u2009\n mVeq<\/jats:styled-content>\n \/h) and negative slopes at\n S3<\/jats:styled-content>\n (\u22121.9\u2009\u00b1\u200929.4\u2009\n mVeq<\/jats:styled-content>\n \/h) (\n S1<\/jats:styled-content>\n \u2013\n S2<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.01;\n S1<\/jats:styled-content>\n \u2013\n S3<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.02). In the prostaglandin group, slopes changed significantly with introduction of drops (\n S1<\/jats:styled-content>\n \u2013\n S2<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009<\u20090.024), whereas they did not in a mixed group combining the three other classes (\n S1<\/jats:styled-content>\n \u2013\n S2<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.060). Overall, cosinor amplitudes were 98.4\u2009\u00b1\u200946.5\u2009\n mVeq<\/jats:styled-content>\n (\n S1<\/jats:styled-content>\n ), 113.0\u2009\u00b1\u200935.6\u2009\n mVeq<\/jats:styled-content>\n (\n S2<\/jats:styled-content>\n ) and 109.6\u2009\u00b1\u200958.3\u2009\n mVeq<\/jats:styled-content>\n (\n S3<\/jats:styled-content>\n ) (\n S1<\/jats:styled-content>\n \u2013\n S2<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.23;\n S1<\/jats:styled-content>\n \u2013\n S3<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.66;\n S2<\/jats:styled-content>\n \u2013\n S3<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.93).\n AUC<\/jats:styled-content>\n were 91.8\u2009\u00b1\u200963.0\u2009\n mVeq<\/jats:styled-content>\n (\n S1<\/jats:styled-content>\n ), 76.3\u2009\u00b1\u2009102.7\u2009\n mVeq<\/jats:styled-content>\n (S2) and 19.9\u2009\u00b1\u2009135.8\u2009\n mVeq<\/jats:styled-content>\n (\n S3<\/jats:styled-content>\n ). Differences between sessions were not statistically significant (\n S1<\/jats:styled-content>\n \u2013\n S2<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.541;\n S1<\/jats:styled-content>\n \u2013\n S3<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.083;\n S2<\/jats:styled-content>\n \u2013\n S3<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.092).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Prostaglandin analogues, but not other medications, seem to flatten the\n IOP<\/jats:styled-content>\n \u2010related increase at transition of the wake\/sitting to the sleep\/supine period, but do not seem to have an effect on acrophase and amplitude.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ceo.12567","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:18:59Z","timestamp":1436228339000},"page":"787-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effect of glaucoma medications on 24\u2010hour intraocular pressure\u2010related patterns using a contact lens sensor"],"prefix":"10.1111","volume":"43","author":[{"given":"Kaweh","family":"Mansouri","sequence":"first","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Center Department of Ophthalmology University of California San Diego California USA"},{"name":"Glaucoma Center, Montchoisi Clinic Genolier Swiss Vision Network Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Center Department of Ophthalmology University of 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