{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:12:48Z","timestamp":1695528768313},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"South Australian Science Excellence Award: Early Career STEM Professional"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>An ibopamine challenge is a novel technique for assessing glaucoma using ibopamine, a topical drug which temporarily increases aqueous production. We aimed to determine whether change in intraocular pressure (IOP<\/jats:styled-content>) and\/or optic cup volume (OCV<\/jats:styled-content>) during the test differentiated between glaucoma patients at different stages of disease; namely, glaucoma suspects (GS<\/jats:styled-content>), glaucoma patients who are stable (SG<\/jats:styled-content>) and glaucoma patients who have demonstrated rapid progression (PG<\/jats:styled-content>).<\/jats:p><\/jats:sec>Design<\/jats:title>Non\u2010randomized clinical trial evaluating a diagnostic test.<\/jats:p><\/jats:sec>Participants<\/jats:title>Sixty\u2010one patients were recruited through glaucoma clinics at the F<\/jats:styled-content>linders M<\/jats:styled-content>edical C<\/jats:styled-content>entre (24 GS<\/jats:styled-content>, 24 SG<\/jats:styled-content> and 13 PG<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients underwent IOP<\/jats:styled-content> measurement and OCV<\/jats:styled-content> assessment using optical coherence tomography. Two drops of ibopamine 2% solution were instilled into the study eye of each patient. After 45\u2009min, IOP<\/jats:styled-content> and OCV<\/jats:styled-content> were reassessed. Changes from baseline were compared between groups.<\/jats:p><\/jats:sec>Main Outcome Measure<\/jats:title>Change in IOP<\/jats:styled-content> and OCV<\/jats:styled-content> after ibopamine challenge.<\/jats:p><\/jats:sec>Results<\/jats:title>Following the ibopamine challenge, IOP<\/jats:styled-content> increased by 1.8\u2009mmHg for GS<\/jats:styled-content> patients, 4.5\u2009mmHg for SG<\/jats:styled-content> patients (P<\/jats:italic>\u2009=\u20090.003) and 8.1\u2009mmHg for PG<\/jats:styled-content> patients (P<\/jats:italic>\u2009<\u20090.0001). OCV<\/jats:styled-content> increased by 0.2% for GS<\/jats:styled-content> patients, 0.6% for SG<\/jats:styled-content> patients and 5.5% for PG<\/jats:styled-content> patients. This was not significantly different between GS<\/jats:styled-content> patients and SG<\/jats:styled-content> patients; however, it was significantly different between GS<\/jats:styled-content> patients and PG<\/jats:styled-content> patients (P<\/jats:italic>\u2009<\u20090.0001), and between SG<\/jats:styled-content> and PG<\/jats:styled-content> patients (P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>GS<\/jats:styled-content> patients may be differentiated from those with SG<\/jats:styled-content> or PG<\/jats:styled-content> by their IOP<\/jats:styled-content> response, and SG<\/jats:styled-content> may be differentiated from PG<\/jats:styled-content> patients by their change in OCV<\/jats:styled-content> following an ibopamine challenge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12569","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T15:59:58Z","timestamp":1435939198000},"page":"808-814","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ibopamine challenge testing differentiates glaucoma suspect, stable glaucoma and progressive glaucoma cases"],"prefix":"10.1111","volume":"43","author":[{"given":"John","family":"Landers","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Department of Ophthalmology Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Flinders Medical Centre Adelaide South Australia 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