{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:45Z","timestamp":1787014005364,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n This study aims to compare the effect of conventional corneal collagen cross\u2010linking (\n CXL<\/jats:styled-content>\n ) with accelerated corneal collagen cross\u2010linking in treatment of keratoconus.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A comparative interventional study was employed.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Participants were consecutive cases of progressive keratoconus receiving either conventional (3\u2009mW\/cm\n 2<\/jats:sup>\n irradiance for 30\u2009min) or accelerated\n CXL<\/jats:styled-content>\n (9\u2009mW\/cm\n 2<\/jats:sup>\n irradiance for 10\u2009min).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Clinical and topographic parameters were compared between the two groups. Postoperative corneal stromal demarcation line was measured using anterior segment optical coherence tomography.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n \n Clinical and topographic parameters such as corrected distant visual acuity (\n CDVA<\/jats:styled-content>\n ), maximum keratometry (\n K<\/jats:styled-content>\n max), mean keratometry (\n K<\/jats:styled-content>\n mean), demarcation line depth were gathered from medical records.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were a total of 26 eyes with an average follow up of 13.9\u2009\u00b1\u20096.3 months. Fourteen eyes received conventional\n CXL<\/jats:styled-content>\n , and 12 eyes had accelerated\n CXL<\/jats:styled-content>\n . In the conventional\n CXL<\/jats:styled-content>\n group,\n CDVA<\/jats:styled-content>\n improved significantly (\n P<\/jats:italic>\n \u2009=\u20090.021). There was also a significant reduction in Kmax (\n P<\/jats:italic>\n \u2009=\u20090.003) and\n K<\/jats:styled-content>\n mean (\n P<\/jats:italic>\n \u2009=\u20090.002). In the accelerated\n CXL<\/jats:styled-content>\n group, no significant changes were found in\n CDVA<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.395),\n K<\/jats:styled-content>\n max (\n P<\/jats:italic>\n \u2009=\u20090.388) and\n K<\/jats:styled-content>\n mean (\n P<\/jats:italic>\n \u2009=\u20090.952) postoperatively. A significantly greater reduction in Kmax and Kmean were seen in conventional\n CXL<\/jats:styled-content>\n compared to its accelerated counterpart (\n P<\/jats:italic>\n \u2009=\u20090.001 and 0.015, respectively). The demarcation line was deeper in eyes with conventional\n CXL<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.013), and the depth correlated significantly with the change in\n K<\/jats:styled-content>\n mean (r\u2009=\u2009\u22120.432,\n P<\/jats:italic>\n \u2009=\u20090.045).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Conventional and accelerated\n CXL<\/jats:styled-content>\n are effective in stabilizing keratoconus progression after a mean of 12 months. Patients undergoing conventional\n CXL<\/jats:styled-content>\n showed clinical improvement with greater corneal flattening, which correlated with a deeper corneal stromal demarcation line. This current study is the first to report such correlation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ceo.12571","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T12:07:33Z","timestamp":1435925253000},"page":"8-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Conventional\n versus<\/i>\n accelerated corneal collagen cross\u2010linking in the treatment of keratoconus"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8321-5634","authenticated-orcid":false,"given":"Alex Lap Ki","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy CY","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology LKS Faculty of Medicine The University of Hong Kong Hong Kong China"},{"name":"Hong Kong Eye Hospital Hospital Authority Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur CK","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hong Kong Sanatorium and Hospital Hong Kong 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