{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:24:23Z","timestamp":1784607863425,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["T.N. 26293372"],"award-info":[{"award-number":["T.N. 26293372"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study is to determine the relationship between post\u2010trabeculectomy bleb structure evaluated using anterior segment optical coherence tomography (AS\u2010OCT) and postoperative intraocular pressure (IOP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Rretrospective is showed for the design of this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>There are twenty\u2010seven eyes of 27 trabeculectomy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We drew contour lines for the bleb and cleft on 8\u2010radius\u2010scanned AS\u2010OCT images, and determined correlations of AS\u2010OCT measurements to postoperative IOP at 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The parameter used in this study is an anterior segment optical coherence tomography measurements of bleb structure, including cleft volume, wall volume, and the brightness of the bleb wall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found significant correlations between postoperative IOP at 6\u2009months and cleft volume at 3 and 6\u2009months (r\u2009=\u2009\u22120.56, <jats:italic>P<\/jats:italic>\u2009=\u20090.007 and <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.82, <jats:italic>P<\/jats:italic>\u2009&lt;0.001), bleb wall volume at 6\u2009months (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.48, <jats:italic>P<\/jats:italic>\u2009=\u20090.042), bleb vertical brightness at 3 and 6\u2009months (<jats:italic>r<\/jats:italic>\u2009=\u20090.73, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>r<\/jats:italic>\u2009=\u20090.49, <jats:italic>P<\/jats:italic>\u2009=\u20090.040), and bleb horizontal brightness at 1\u2009week, 2\u2009weeks, 3\u2009months and 6\u2009months (<jats:italic>r<\/jats:italic>\u2009=\u20090.49, <jats:italic>P<\/jats:italic>\u2009=\u20090.016, <jats:italic>r<\/jats:italic>\u2009=\u20090.65, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>r<\/jats:italic>\u2009=\u20090.52, <jats:italic>P<\/jats:italic>\u2009=\u20090.013 and <jats:italic>r<\/jats:italic>\u2009=\u20090.71, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). A stepwise multiple regression analysis of bleb structural measurements made \u22642\u2009weeks postoperatively showed that the strongest independent factor indicating postoperative IOP at 6\u2009months was bleb horizontal brightness at 2\u2009weeks (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.50, <jats:italic>P<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early postoperative AS\u2010OCT measurements of blebs, especially horizontal brightness of the bleb wall, were associated with postoperative IOP at 6\u2009months. AS\u2010OCT measurements of blebs may be useful predictors of trabeculectomy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12689","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T14:21:11Z","timestamp":1449152471000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quantification of the filtering bleb's structure with anterior segment optical coherence tomography"],"prefix":"10.1111","volume":"44","author":[{"given":"Taiki","family":"Kokubun","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kunikata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Retinal Disease Control Tohoku University 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