{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:11:22Z","timestamp":1774026682143,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare visual and anatomical outcomes between intravitreous bevacizumab (BVB, Avastin) and triamcinolone (TA, Triesence) when administered at the time of cataract surgery in patients with diabetic macular oedema (DME).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, single\u2010masked, randomized clinical trial at The Royal Victorian Eye and Ear Hospital, Melbourne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with clinically significant cataract and either centre\u2010involving DME or DME treated within the previous 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were randomized 1:1 to receive intravitreous BVB 1.25\u2009mg or TA 4\u2009mg during cataract surgery, and at subsequent review if required over 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Change in central macular thickness (CMT) and best corrected visual acuity at 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients (mean age 66.4\u2009years, 73.2% male) were recruited. Visual acuity and CMT were similar between groups at baseline (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.2).After six months, both groups gained vision (mean +21.4 letters in TA group <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, +12.5 letters in BVB, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), with no significant difference between groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.085). In addition, 60.9% of eyes receiving TA achieved a VA of \u22656\/12 compared to 73.3% in the BVB group (<jats:italic>P<\/jats:italic>\u2009=\u20090.501). However, only TA was associated with a sustained reduction in CMT (\u221243.8\u2010\u00b5m reduction TA vs. +37.3\u2010\u00b5m increase BVB, <jats:italic>P<\/jats:italic>\u2009=\u20090.006 over 6\u2009months). Following surgery, additional injections were required in 70.6% of participants in the BVB group, compared to 16.7% in the TA group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Three patients in the TA group experienced a rise of IOP over 21\u2009mmHg (12.5%) during the 6\u2010month follow\u2010up; BVB had no cases (<jats:italic>P<\/jats:italic>\u2009=\u20090.130). There were no cases of endophthalmitis in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When administered at the time of cataract surgery in patients with DME, at 6\u2009months both TA and BVB improve visual acuity; however, only TA results in a sustained reduction in CMT. Further follow\u2010up will determine whether this translates into better long\u2010term visual outcomes in the TA group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12720","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T15:49:14Z","timestamp":1455292154000},"page":"233-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Diabetic Macular Edema at the time of Cataract Surgery trial: a prospective, randomized clinical trial of intravitreous bevacizumab versus triamcinolone in patients with diabetic macular oedema at the time of cataract surgery \u2013 preliminary 6 month results"],"prefix":"10.1111","volume":"44","author":[{"given":"Lyndell L","family":"Lim","sequence":"first","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital; Ophthalmology, University of Melbourne, Department of Surgery  Melbourne Victoria Australia"},{"name":"Medical Retina Clinic Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L","family":"Morrison","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital; Ophthalmology, University of Melbourne, Department of Surgery  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Constantinou","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital; Ophthalmology, University of Melbourne, Department of Surgery  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Rogers","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital; Ophthalmology, University of Melbourne, Department of Surgery  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhpal S","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital; Ophthalmology, University of Melbourne, Department of Surgery  Melbourne Victoria Australia"},{"name":"Medical Retina Clinic Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeewa S","family":"Wickremasinghe","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital; 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