{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:51:45Z","timestamp":1776329505599,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the possible mechanisms by which cataract surgery aggravates meibomian gland dysfunction (MGD), we evaluated the changes in tear cytokines and ocular surface parameters after cataract surgery according to the preoperative MGD grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, observational case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 50 eyes from 50 patients who underwent cataract surgery were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were classified into two groups: Group I had no or minimal MGD, and group II had grades 2\u20134 MGD. Ocular surface parameters were measured, including tear film break\u2010up time, Schirmer I test, ocular surface staining and Ocular Surface Disease Index, and tear cytokine levels were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The main outcomes were changes in ocular surface parameters and inflammatory tear cytokine concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In group II, preoperative MGD grade, ocular surface staining, tear film break\u2010up time and Ocular Surface Disease Index were worse, and mean interleukin (IL)\u20102, IL\u20106 and TNF\u2010\u03b1 levels were higher than those of group I. MGD and ocular surface parameters were worsened to a greater degree after surgery in group II than in group I (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.050). In group II, IL\u20106 and TNF\u2010\u03b1 levels significantly increased at postoperative 1\u2009month, and there were significant correlations between changes in ocular surface parameters and tear cytokines (IL\u20102, IL\u20106 and TNF\u2010\u03b1; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extent to which the MGD grade was aggravated following cataract surgery differed based on preoperative MGD grade. Preoperative MGD and ocular surface status should be carefully evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12744","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T11:51:47Z","timestamp":1458301907000},"page":"555-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Meibomian gland dysfunction and tear cytokines after cataract surgery according to preoperative meibomian gland status"],"prefix":"10.1111","volume":"44","author":[{"given":"Ji Won","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Ophthalmology, Inha Vision Science Laboratory Inha University School of Medicine  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Jung","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Min","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHA Bundang Medical Center CHA University  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010im","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung Kweon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Vision Research, Severance Biomedical Science Institute, Brain Korea 21 Plus Project for Medical Science Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Yul","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31812f67ca"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31816f6854"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-012-0117-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-010-0858-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.02.036"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000150445"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.08.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997a"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34669-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.06.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.04.037"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199801000-00007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200310000-00008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.615"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.04.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02499.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273949709085060"},{"key":"e_1_2_6_19_1","first-page":"2400","article-title":"IL\u20106 induction in desiccated corneal epithelium in vitro and in vivo","volume":"17","author":"Higuchi A","year":"2011","journal-title":"Mol Vis"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.19.3.201.5309"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31803dcda2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.33"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2008.0116"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00082-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2010.0110"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1039-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.08.015"}],"container-title":["Clinical &amp; 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