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Following an asymptomatic phase of hyperuricaemia, gout usually presents as acute monoarthritis followed by periods of remission and exacerbation. Conjunctival hyperaemia and subconjunctival haemorrhage exacerbated by purine intake are two of the more common manifestations that may go unrecognized. Other ocular and adnexal structures can be affected by urate crystal deposition and associated inflammation, with potentially vision\u2010threatening consequences; however, ocular manifestations of gout are rare and may have been over\u2010reported in the older literature, but our understanding of the clinic\u2010pathological features of ocular urate deposits remains limited.<\/jats:p>","DOI":"10.1111\/ceo.12749","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T17:05:04Z","timestamp":1458839104000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Review of the ophthalmic manifestations of gout and uric acid crystal deposition"],"prefix":"10.1111","volume":"45","author":[{"given":"Jack","family":"Ao","sequence":"first","affiliation":[{"name":"South Australian Institute of Ophthalmology University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Goldblatt","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Repatriation General Hospital  Adelaide South Australia Australia"},{"name":"Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Casson","sequence":"additional","affiliation":[{"name":"South Australian Institute of Ophthalmology University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60883-7"},{"key":"e_1_2_3_3_1","first-page":"925","article-title":"Gout and hyperuricemia","volume":"59","author":"Harris MD","year":"1999","journal-title":"Am Fam Physician"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rhu.0000182195.26541.d7"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110001108"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347542"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68894-6"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.mpmed.2006.07.012"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204463"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2519"},{"key":"e_1_2_3_12_1","volume-title":"National Health Survey: First Result","author":"National Health Survey: First Result","year":"1995"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02794.x"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker361"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16000-5"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035700"},{"key":"e_1_2_3_17_1","first-page":"1","article-title":"Fructose: metabolism and short\u2010term effects on carbohydrate and purine metabolic pathways","volume":"21","author":"Van den Berghe G","year":"1986","journal-title":"Prog Biochem Pharmacol"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22762"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34677"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes211"},{"key":"e_1_2_3_21_1","first-page":"617","article-title":"Community based study to estimate prevalence, burden of illness and help seeking behavior in rheumatic diseases in Mexico City. 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