{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:34:13Z","timestamp":1792114453603,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ophthalmic herpes simplex viral keratitis is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different ophthalmic herpes simplex viral keratitis disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.<\/jats:p>","DOI":"10.1111\/ceo.12785","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T03:50:16Z","timestamp":1465357816000},"page":"824-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents"],"prefix":"10.1111","volume":"44","author":[{"given":"Michael","family":"Tsatsos","sequence":"first","affiliation":[{"name":"Royal Eye Infirmary Dorset County Hospital NHS Foundation Trust  Dorchester UK"},{"name":"Southampton University Hospitals NHS Foundation Trust  Southampton UK"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"MacGregor","sequence":"additional","affiliation":[{"name":"Southampton University Hospitals NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Athanasiadis","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilita M","family":"Moschos","sequence":"additional","affiliation":[{"name":"University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parwez","family":"Hossain","sequence":"additional","affiliation":[{"name":"Southampton University Hospitals NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Anderson","sequence":"additional","affiliation":[{"name":"Southampton University Hospitals NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020226030"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f771f"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200101000-00001"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01772-4"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.69.1.2"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.6.560"},{"key":"e_1_2_19_8_1","first-page":"2501","volume-title":"Fields Virology 2","author":"Roizman R","year":"2007"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.05.001"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9441"},{"key":"e_1_2_19_11_1","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1128\/jvi.62.9.3493-3496.1988","article-title":"Latent herpes simplex virus type 1 transcription in human trigeminal ganglia","volume":"62","author":"Steiner I","year":"1988","journal-title":"Journal of Virology"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2434993"},{"key":"e_1_2_19_13_1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1128\/jvi.63.7.2893-2900.1989","article-title":"A deletion in mutant of the latency\u2010associated transcription of herpes simplex virus type 1 reactivates from the latent state with reduced frequency","volume":"63","author":"Leib DA","year":"1989","journal-title":"Journal of Virology"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.76.7.412"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.17.11142-11150.2005"},{"key":"e_1_2_19_16_1","first-page":"1617","article-title":"Psychological stress and other potential triggers for recurrences of herpes simplex virus eye infections. 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