{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:41:13Z","timestamp":1776901273669,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine if pretreatment with antifungal agents is predictive of worse clinical outcome in a fungal keratitis clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Non\u2010pre\u2010specified subgroup analysis of a randomized controlled trial in a tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Three hundred twenty\u2010three fungal ulcer cases with an enrolment visual acuity of 20\/40 to 20\/400.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Mycotic Ulcer Treatment Trial I was a randomized, double\u2010masked trial to determine the optimal treatment for filamentous fungal keratitis at the Aravind Eye Care System, India. Enrolled cases were randomized to receive topical natamycin or voriconazole. Prior antifungal medication use, dose and duration were collected at enrolment. A subgroup analysis was performed to determine if patients using natamycin or azoles at presentation have worse clinical outcomes compared with those who were not pretreated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Three\u2010month visual acuity (primary), 3\u2010month infiltrate or scar size, corneal perforation and\/or transplant and re\u2010epithelialization time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 323 patients enrolled, 44% presented on an antifungal agent. Pretreated patients had larger mean baseline infiltrate size (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and epithelial defect size (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Multivariate regression analysis demonstrated that pretreatment was associated with significantly worse 3\u2010month visual acuity (<jats:italic>P<\/jats:italic>\u2009=\u20090.006), larger 3\u2010month scar size (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and increased odds of corneal perforation and\/or transplant (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fungal keratitis that is smear\u2010positive despite being pretreated with appropriate antifungal agents appears to be a risk factor for worse outcomes, likely a result of initial ulcer severity and treatment failure. These patients may benefit from more aggressive multimodal therapy at a tertiary centre.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12794","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:22:52Z","timestamp":1466630572000},"page":"763-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of pretreatment with antifungal agents on clinical outcomes in fungal keratitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Catherine Q","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Venkatesh","family":"Prajna","sequence":"additional","affiliation":[{"name":"Aravind Eye Care System at Madurai, Pondicherry and Coimbatore  Madurai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiruvengada","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Aravind Eye Care System at Madurai, Pondicherry and Coimbatore  Madurai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revathi","family":"Rajaraman","sequence":"additional","affiliation":[{"name":"Aravind Eye Care System at Madurai, Pondicherry and Coimbatore  Madurai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthiah","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Aravind Eye Care System at Madurai, Pondicherry and Coimbatore  Madurai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Aravind Eye Care System at Madurai, Pondicherry and Coimbatore  Madurai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran S","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of California San Francisco  San Francisco California USA"},{"name":"Francis I. Proctor Foundation University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha R","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of California San Francisco  San Francisco California USA"},{"name":"Francis I. Proctor Foundation University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rose\u2010Nussbaumer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of California San Francisco  San Francisco California USA"},{"name":"Francis I. Proctor Foundation University of California San Francisco  San Francisco California USA"},{"name":"Department of Optometry University of California Berkeley  Berkeley California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Mycotic Ulcer Treatment Trial Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200403000-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.45"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.1718"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.1497"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:18:10Z","timestamp":1696360690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/ceo.12794"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12794","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]},"assertion":[{"value":"2015-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}