{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:30:28Z","timestamp":1780626628649,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research to Prevent Blindness Departmental Grant"},{"name":"Eye and Ear Foundation of Pittsburgh, Initiative to Cure Glaucoma"},{"name":"Department of Ophthalmology, University of Pittsburgh"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the outcomes of trabectome\u2010mediated ab interno trabeculectomy in patients with steroid\u2010induced glaucoma (SIG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective, observational cohort study performed in the Department of Ophthalmology, University of Pittsburgh Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The data of 60 patients with SIG and 484 controls with primary open\u2010angle glaucoma (POAG) matched by age, gender and glaucoma index were collected from the Trabectome Study Group database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Reduction of intraocular pressure (IOP) and medications were compared between POAG and SIG by multivariate regression. Kaplan\u2013Meier was used for survival analysis. Success was defined as IOP \u226421\u2009mmHg and at least 20% IOP reduction from baseline for any two consecutive visits after 3\u2009months without secondary glaucoma surgery. Postoperative IOP and number of medications were compared with baseline in the SIG subgroups by the Wilcoxon test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Intraocular pressure reduction and 1\u2010year success rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with SIG had a higher baseline IOP (31.4\u2009\u00b1\u200910.4<jats:italic>vs<\/jats:italic>. 24.1\u2009\u00b1\u20097.6\u2009mmHg,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and obtained a greater IOP reduction than controls with POAG (48.4%<jats:italic>vs<\/jats:italic>. 31.5%,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Multivariate regression showed that patients with SIG had an IOP reduction of 6.7\u2009\u00b1\u20091.1\u2009mmHg more than those with POAG. Survival rates at 12\u2009months were comparable at 86% in the SIG group and 85% in the POAG group (<jats:italic>P<\/jats:italic>\u2009=\u20090.47). Patients with SIG with a high baseline IOP, younger age and advanced glaucoma experienced a larger IOP drop.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trabectome appears to be an effective surgical treatment in reducing IOP for patients with SIG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12796","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T01:22:43Z","timestamp":1466817763000},"page":"783-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Steroid\u2010induced glaucoma treated with trabecular ablation in a matched comparison with primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"44","author":[{"given":"Yalong","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kaplowitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Loma Linda University Veterans Affairs Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardik A","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Institute of Ophthalmology and Visual Science Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitsa T","family":"Loewen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of California, Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils A","family":"Loewen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.04.029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328630"},{"key":"e_1_2_6_4_1","first-page":"1769","article-title":"Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues","volume":"42","author":"Clark AF","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12801"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13088"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.09.022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701895"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200406000-00016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811104020110"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088378"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149384"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151926"},{"key":"e_1_2_6_14_1","unstructured":"NeiweemAE BusselII SchumanJS BrownEN LoewenNA.Glaucoma surgery calculator: limited additive effect of phacoemulsification on intraocular pressure in ab interno trabeculectomy. 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