{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:14:22Z","timestamp":1792458862955,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council Early Career Fellowship","award":["#1109330"],"award-info":[{"award-number":["#1109330"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endogenous <jats:italic>Klebsiella pneumoniae<\/jats:italic> endophthalmitis (EKPE) is a well\u2010known entity in South\u2010East Asia. We demonstrate a range of differing clinical features and outcomes of EKPE, and highlight the increasing incidence of EKPE in major centres in Sydney and Melbourne, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective observational case study and case series in the hospital setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Four cases of EKPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EKPE cases from 2005 to 2015 were identified through established endophthalmitis databases as well as hospital\u2010based microbiological searches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>EKPE cases were confirmed with positive <jats:italic>K. pneumoniae<\/jats:italic> intraocular samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rising trends of EKPE were noted in major centres in Australia. Six eyes of four patients with EKPE from January 2011 to December 2015 are reported. The mean age was 49\u2009years (range 43\u201358\u2009years). Two patients had bilateral involvement. There were systemic symptoms up to 10\u2009days prior to ocular symptoms. The source of sepsis in all cases was a hepatic abscess. Two patients had diabetes mellitus. Five eyes had hypopyon panuveitis on presentation. All eyes underwent vitrectomy. The patient with the most delayed presentation underwent enucleation following globe perforation. Final best corrected visual acuity (BCVA) in one patient with bilateral EKPE was light perception (LP) only. The other three eyes had BCVA in at least one eye of 6\/24 or better.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EKPE is an emerging condition in Australia. Although rare, EKPE is a sight\u2010threatening and potentially life\u2010threatening emergency that can initially present to ophthalmologists. One should suspect EKPE in septic patients with a B\u2010scan showing a vitreous or retinal abscess.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12827","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T23:06:45Z","timestamp":1472252805000},"page":"135-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Rising trends of endogenous <i>Klebsiella pneumoniae<\/i> endophthalmitis in Australia"],"prefix":"10.1111","volume":"45","author":[{"given":"Capucine","family":"Odouard","sequence":"first","affiliation":[{"name":"Sydney Hospital and Sydney Eye Hospital  Sydney New South Wales Australia"},{"name":"Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daini","family":"Ong","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia University of Melbourne  East Melbourne Victoria 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