{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:52:00Z","timestamp":1781650320912,"version":"3.54.5"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004305","name":"Shahroud University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine retinal nerve fibre layer (RNFL) thickness distribution and its related factors in a general population of 45 to 69\u2009year olds in Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Of the 5190 participants of phase one of Shahroud Eye Cohort Study, 4737 participated in Phase two (participation rate\u2009=\u200991.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All study participants underwent visual acuity measurement, refraction tests, slit lamp examination and ophthalmoscopic fundus exam. Tests also included imaging with Cirrus HD\u2010OCT 4000 and its RNFL thickness data were used in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The overall RNFL thickness and the average RNFL thickness in different quadrants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean RNFL thickness in the superior, inferior, nasal and temporal quadrants were 92.47\u2009\u00b5m [95% confidence interval (CI): 92.14\u201392.80], 111.22\u2009\u00b5m (95% CI: 110.7\u2013111.73), 118.93\u2009\u00b5m (95% CI: 118.31\u2013119.55), 74.83\u2009\u00b5m (95% CI: 74.07\u201375.59) and 65.48\u2009\u00b5m (95% CI: 65.06\u201365.90). Multiple linear regression models indicated that RNFL thickness in all quadrants decreased with ageing, was lower in females (coefficient:\u20130.87 and <jats:italic>P<\/jats:italic>\u2009=\u20090.015), decreased by 1.42\u2009\u00b5m (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) for each millimetre increase in axial length and decreased by 0.41\u2009\u00b5m (<jats:italic>P<\/jats:italic>\u2009=\u20090.041) for each diopter decrease in spherical equivalent refraction of myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RNFL thickness in the 45 to 69\u2010year\u2010old Iranian population is lower compared to other studies. This difference should be noted in making disease diagnoses, particularly glaucoma. Also, there is a significant relationship between ageing and RNFL thinning in all quadrants. Longer axial length, myopia and male gender are associated with reduced RNFL thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12849","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T16:00:42Z","timestamp":1476374442000},"page":"261-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retinal nerve fibre layer thickness in a general population in Iran"],"prefix":"10.1111","volume":"45","author":[{"given":"Hassan","family":"Hashemi","sequence":"first","affiliation":[{"name":"Noor Research Center for Ophthalmic Epidemiology Noor Eye Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Khabazkhoob","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Nursing, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Noor Ophthalmology Research Center Noor Eye Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Nabovati","sequence":"additional","affiliation":[{"name":"Noor Ophthalmology Research Center Noor Eye Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbasali","family":"Yekta","sequence":"additional","affiliation":[{"name":"Department of Optometry, School of Paramedical Sciences Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Emamian","sequence":"additional","affiliation":[{"name":"Center for Health Related Social and Behavioral Sciences Research Shahroud University of Medical Sciences  Shahroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Fotouhi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0110"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.036"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000188705.67815.0e"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.026"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2013.04.007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.08.003"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2009.02015.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.032"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0514"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181c4b0c7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2006.08.046","article-title":"Determinants of normal retinal nerve fiber layer thickness measured by stratus OCT","volume":"114","author":"Budenz DL","journal-title":"Ophthalmology"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.196782"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181fc8053"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopthalmol.2011.1576"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.08.046"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12240"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01296-4"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070634"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.09.004"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0975"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000212215.12180.19"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1174"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.06.039"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-1140-y"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.49"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31814b9817"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0800"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.129502"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.020"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000138205.99424.24"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-008-0538-6"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.6.827"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.08.069"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2005.19.4.281"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.023"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.21608"},{"key":"e_1_2_5_38_1","first-page":"303","article-title":"Quantification of the retinal nerve fibre layer thickness in normal Indian eyes with optical coherence tomography","volume":"52","author":"Sony P","year":"2004","journal-title":"Indian J Ophthalmol"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.12.045"},{"key":"e_1_2_5_40_1","first-page":"165","article-title":"Evaluation of the effect of aging on retinal nerve fiber thickness of normal Japanese measured by optical coherence tomography","volume":"110","author":"Yamada H","year":"2006","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.12.032"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.061"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02438.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181bdb55d"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.06.024"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.216"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100050054031"},{"key":"e_1_2_5_48_1","first-page":"524","article-title":"Optical coherence tomography in measuring retinal nerve fiber layer thickness in normal subjects and patients with open\u2010angle glaucoma","volume":"114","author":"Liu X","year":"2001","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.11.1579"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.899"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(84)90509-9"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020040905024"},{"key":"e_1_2_5_53_1","first-page":"736","article-title":"Histomorphometry of the human optic nerve","volume":"31","author":"Jonas JB","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12658"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e318255bb4a"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.103797"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3182358008"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4737"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.244"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-13880"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.116466"},{"key":"e_1_2_5_62_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/IJG.0b013e3181f3eb64","article-title":"Reproducibility of retinal nerve fiber layer thickness measurements using spectral domain optical coherence tomography","volume":"20","author":"Wu H","year":"2011","journal-title":"J Glaucoma"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12131"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.3126\/nepjoph.v6i2.11709"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12849","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:31:47Z","timestamp":1696303907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,8]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/ceo.12849"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12849","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,8]]},"assertion":[{"value":"2016-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}