{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:28:23Z","timestamp":1784989703154,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21 EY022989"],"award-info":[{"award-number":["R21 EY022989"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities and antibiotic prophylaxis in culture\u2010proven endophthalmitis cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective consecutive case series and community\u2010based setting were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Two hundred fifteen cases of endophthalmitis after cataract surgery performed during 2007\u20132012 in Kaiser Permanente, California.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Main Outcome Measures<\/jats:title><jats:p>Descriptive analysis of isolated organisms and antibiotic sensitivities in relation to antibiotic prophylaxis in culture\u2010proven endophthalmitis cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of culture\u2010confirmed organisms (<jats:italic>n<\/jats:italic>\u00a0=\u00a083) were Gram positive (96%), most notably coagulase\u2010negative <jats:italic>Staphylococci<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a034, 52%), of which all that underwent testing were sensitive to vancomycin (<jats:italic>n<\/jats:italic>\u00a0=\u00a032). Among 19 cases that had received only topical antibiotic prophylaxis, seven (37%) were resistant to the antibiotic given: 50% of cases (5 of 10 isolates) that had received ofloxacin were resistant to this antibiotic, 40% (2 of 5 isolates) that had received gatifloxacin were resistant. In contrast, 100% of cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) that had received aminoglycosides were susceptible. Few culture\u2010confirmed cases occurred in patients who received intracameral antibiotic (<jats:italic>n<\/jats:italic>\u00a0=\u00a04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cases where fluoroquinolones were administered as antibiotic prophylaxis, isolates demonstrated a degree of bacterial resistance. The majority of endophthalmitis cases isolated occured following topical antibiotic prophylaxis only and were attributed to Gram\u2010positive organisms, while few occurred in association with intracameral antibiotic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12910","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T23:32:47Z","timestamp":1482708767000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pathogens and antibiotic sensitivities in endophthalmitis"],"prefix":"10.1111","volume":"45","author":[{"given":"Geraldine R","family":"Slean","sequence":"first","affiliation":[{"name":"Department of Ophthalmology California Pacific Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal H","family":"Shorstein","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology and Quality Kaiser 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