{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T18:24:41Z","timestamp":1748283881753},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A characteristic disease pattern may be reflected by retinal layer thickness changes in non\u2010arteritic anterior ischaemic optic neuropathy measured using spectraldomain optical coherence tomography. Retinal layer segmentation is enabled by advanced software. In this study, retinal layer thicknesses in acute and chronic non\u2010arteritic anterior ischaemic optic neuropathy were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A single\u2010centre cross\u2010sectional analysis was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 27 patients (20 age\u2010matched healthy eyes) were included: 14 with acute (&lt;7 days) and 13 patients with chronic non\u2010arteritic anterior ischaemic optic neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Macular volume and 12\u00b0 peripapillary ring optical coherence tomography scans were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The peripapillary thicknesses of the following layers were determined by manual segmentation: retinal nerve fibres, ganglion cells + inner plexiform layer, inner nuclear layer + outer plexiform layer, outer nuclear layer + inner segments of the photoreceptors and outer segments of the photoreceptors to Bruch's membrane. Macular retinal layer thicknesses were automatically determined in volume cubes centred on the fovea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peripapillary retinal swelling in acute nonarteritic anterior ischaemic optic neuropathy was attributable to retinal nerve fibre layer, ganglion cell layer\/inner plexiform layer and outer nuclear layer\/segments of the photoreceptors thickening. In chronic cases, peripapillary retinal nerve fibre layer, macular ganglion cell layer and inner plexiform layer thinning were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In acute non\u2010arteritic anterior ischaemic optic neuropathy, the inner and outer peripapillary retinal layers are affected by thickness changes. In chronic cases, atrophy of the ganglion cells and their axons and dendrites is evident by inner retinal layer thinning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12914","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T09:49:08Z","timestamp":1485769748000},"page":"496-508","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alterations of the outer retina in non\u2010arteritic anterior ischaemic optic neuropathy detected using spectral\u2010domain optical coherence tomography"],"prefix":"10.1111","volume":"45","author":[{"given":"Philipp","family":"Ackermann","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"Brachert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of D\u00fcsseldorf  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