{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:24:17Z","timestamp":1783693457601,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Blepharitis is one of the most common conditions. However, no study has yet evaluated the epidemiology by evaluating a large population\u2010based sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the incidence and prevalence of clinically diagnosed blepharitis in South Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Nationwide population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>We investigated the Korean National Health Insurance Service\u2010National Sample Cohort, a representative one million\u2010sample of the Korean population, for patients diagnosed with blepharitis according to the Korean Classification of Diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Annual and overall incidence and prevalence of blepharitis during the study period (2004\u20132013) were estimated after excluding chronic blepharitis patients, diagnosed during 2002\u20132003. Sociodemographic factors and comorbidities associated with blepharitis were evaluated using Cox proportional hazard regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The first occurrence of blepharitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1\u00a0116\u00a0363 individuals over 9\u00a0698\u00a0118\u00a0person\u2010years were evaluated (mean follow up: 8.7\u00a0years) from 2004 to 2013. The overall incidence was 1.1 (95% confidence interval, 1.1\u20131.1) per 100\u00a0person\u2010years. The incidence increased with time (0.9 <jats:italic>vs<\/jats:italic>. 1.3 per 100\u00a0person\u2010years, in 2004 and 2013, respectively) and was higher in female patients (1.3 <jats:italic>vs<\/jats:italic>. 0.9 per 100\u00a0person\u2010years, respectively). The overall prevalence was 8.1% (95% confidence interval: 8.0\u20138.1) among subjects aged 40\u00a0years or older. Chalazion, gastritis, Sj\u00f6gren's syndrome, pterygium, rosacea, prostatic hypertrophy, atopy, irritable bowel disease and peptic ulcer were associated with an increased incidence of blepharitis in the multivariable Cox model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that blepharitis was a relatively common disease and is associated with various ocular and systemic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12929","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:25:06Z","timestamp":1486686306000},"page":"448-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ten\u2010year incidence and prevalence of clinically diagnosed blepharitis in South Korea: a nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"45","author":[{"given":"Tyler Hyungtaek","family":"Rim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Ophthalmology National Health Insurance Service Ilsan Hospital  Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jae","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonjung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Yul","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Healthcare Big Data Based Knowledge Integration System Research Center Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Convergence Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70622-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70620-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv319"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-1271027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005556.pub2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(96)80064-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34669-2"},{"key":"e_1_2_7_12_1","first-page":"200","article-title":"Chronic blepharitis: a review","volume":"21","author":"Smith RE","year":"1995","journal-title":"CLAO J"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71688-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703101"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-007614"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2014.42585"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(00)00200-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.12.1667"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000167"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)96016-X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00262-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703101"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.08.021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archderm.1997.03890370095014","article-title":"Ocular rosacea. 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