{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:40:13Z","timestamp":1773528013640,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medicine Science\/Engineering Hybrid Project of Shanghai Jiaotong University","award":["YG2013 MS09"],"award-info":[{"award-number":["YG2013 MS09"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Identifying changes of peripapillary vessel density in highly myopic eyes with peripapillary intrachoroidal cavitation by optical coherence tomography angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate peripapillary vessel density and its relationship with other ocular parameters in highly myopic eyes with peripapillary intrachoroidal cavitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Hospital\u2010based, cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010five highly myopic eyes with peripapillary intrachoroidal cavitation, 46 highly myopic eyes without peripapillary intrachoroidal cavitation and 36 normal eyes were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants underwent optical coherence tomography angiography to image the retinal vasculature in the peripapillary areas, including the radial peripapillary capillaries and optic nerve head layer. Correlations between vessel density and ocular metrics were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Peripapillary vessel density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In highly myopic eyes, vessel density was significantly lower in eyes with peripapillary intrachoroidal cavitation than in those without in peripapillary (<jats:italic>P<\/jats:italic> = 0.014, <jats:italic>P<\/jats:italic> = 0.037), inferotemporal (<jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>P<\/jats:italic> &lt; 0.001) and superotemporal (<jats:italic>P<\/jats:italic> = 0.014, <jats:italic>P<\/jats:italic> = 0.009) areas. In the radial peripapillary capillaries layer, vessel density was negatively correlated with peripapillary atrophy area (<jats:italic>P<\/jats:italic> = 0.012) and myopic maculopathy (<jats:italic>P<\/jats:italic> = 0.002), and in the optic nerve head layer, it was negatively associated with a diagnosis of peripapillary intrachoroidal cavitation (<jats:italic>P<\/jats:italic> = 0.012) and myopic maculopathy (<jats:italic>P<\/jats:italic> &lt; 0.001). In addition, it was positively correlated with retinal nerve fibre layer thickness in both layers (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Highly myopic eyes with peripapillary intrachoroidal cavitation had lower peripapillary vessel densities, especially in the temporal area, than those without.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12986","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T23:02:47Z","timestamp":1494543767000},"page":"884-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exploration of peripapillary vessel density in highly myopic eyes with peripapillary intrachoroidal cavitation and its relationship with ocular parameters using optical coherence tomography angiography"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1718-6705","authenticated-orcid":false,"given":"Qiuying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shanghai General Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangnan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai General Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai General Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7347.1195"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.11.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.1994.tb00128.x"},{"key":"e_1_2_5_5_1","first-page":"2486","article-title":"Prevalence and risk factors for refractive errors in adult Chinese in Singapore","volume":"41","author":"Wong TY","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000309243"},{"key":"e_1_2_5_7_1","first-page":"67","article-title":"The posterior staphyloma of pathologic myopia","volume":"75","author":"Curtin BJ","year":"1977","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.2.197"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.1.46"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.016"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702666"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.063"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702961"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318242b9c0"},{"key":"e_1_2_5_15_1","first-page":"113","article-title":"Choroidal and retinal blood flow changes in degenerative myopia","volume":"31","author":"Akyol N","year":"1996","journal-title":"Can J Ophthalmol"},{"key":"e_1_2_5_16_1","first-page":"1261","article-title":"Some features of ocular microcirculation in myopia","volume":"9","author":"Avetisov ES","year":"1977","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1407-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00170692"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0836-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.08.028"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.034"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.003127"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.021"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16270"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2225"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18944"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3095-y"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.08.076"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047237"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11255"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.006"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.022"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00284-0"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010791"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.16"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12796"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.10.020"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18630"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S102130"},{"key":"e_1_2_5_40_1","article-title":"Peripapillary intrachoroidal cavitations","volume":"8","author":"You QS","year":"2013","journal-title":"The Beijing eye study PloS one"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.08.041"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:52:41Z","timestamp":1695995561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/ceo.12986"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12986","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,15]]},"assertion":[{"value":"2016-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}