{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:36:53Z","timestamp":1773387413263,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>In a subset of patients with retinal vasculitis, there is occlusion of blood flow through the retinal vessels. These eyes are at high risk of sight\u2010threatening complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To characterize epidemiology, clinical course, treatment and outcomes of occlusive retinal vasculitis (ORV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Seventy\u2010seven uveitis patients with ORV at two large tertiary\u2010care institutions (the USA and India).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Out of 2438 patients screened, 346 patients were diagnosed with retinal vasculitis of which 77 patients (96 eyes) were diagnosed with ORV. Patients with ORV (capillary, arteriolar and\/or venular) were further analysed. Diagnostic criteria for occlusive vasculitis included (i) absence of blood flow in vessels (arterioles, venules and\/or capillaries), (ii) capillary non\u2010perfusion areas and\/or arteriolar\u2010venous anastomosis and (iii) intraretinal haemorrhages, cotton\u2010wool spots or vitreous haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Best\u2010corrected visual acuity, treatment and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 32.09\u00a0\u00b1\u00a013.51\u00a0years. Most common aetiologies were tuberculosis and Adamantiades\u2013Beh\u00e7et's disease in India and systemic lupus erythematosus in the USA. Best\u2010corrected visual acuity improved from 0.38\u00a0\u00b1\u00a00.30 logMAR (20\/48 Snellen equivalent) (baseline) to 0.25\u00a0\u00b1\u00a00.30 (20\/35 Snellen equivalent) at final visit (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Vitreous haemorrhage was seen in 31.08% eyes. Pars plana vitrectomy was performed in 12.16% eyes. Therapy with systemic steroids was required in 78.48% patients. In addition, 46.75% patients required immunomodulators and\/or biologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occlusive retinal vasculitis is caused by heterogeneous group of uveitides depending upon the geographic location. It is imperative to identify eyes with ORV as they are predisposed to complications requiring aggressive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12997","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T16:26:37Z","timestamp":1496075197000},"page":"62-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Epidemiology and clinical features of inflammatory retinal vascular occlusions: pooled data from two tertiary\u2010referral institutions"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-9855","authenticated-orcid":false,"given":"Aniruddha","family":"Agarwal","sequence":"first","affiliation":[{"name":"Ocular Imaging Research and Reading Center (OIRRC)  Menlo Park California USA"},{"name":"Advanced Eye Center, Department of Ophthalmology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh 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