{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:52:49Z","timestamp":1764841969830,"version":"3.37.3"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005890","name":"Ministry of Health of the People's Republic of China","doi-asserted-by":"publisher","award":["201002019"],"award-info":[{"award-number":["201002019"]}],"id":[{"id":"10.13039\/501100005890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>The data may support the notion that the intra\u2010ocular pressure (IOP)\u2010related factors and vascular factors were implicated concurrently in glaucomatous optic nerve damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To study the association of intraocular pressure (IOP)\u2010related factors, IOP, trans\u2010lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro\u2010retinal rim area (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A population\u2010based, cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 6830 people aged 30\u2009years and over.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants underwent a comprehensive eye examination, fundus photograph\u2010based measurements of RVD and Heidelberg retinal tomogram (HRT) measurement of optic disc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>RA, CRAE, CRVE, IOP, body mass index (BMI), CSFP and TLCPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary open\u2010angle glaucoma (POAG) was diagnosed using two separate methods: 67 from expert consensus, and 125 from the International Society of Geographical and Epidemiologic Ophthalmology (ISGEO) classification. After excluding of those with high myopia or without gradable HRT images, 4194 non\u2010glaucoma and 40 POAG were analysed for determinants of RA. On multivariable analysis determinants of reduced RA were POAG (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), higher IOP (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), higher refractive error (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), longer axial length (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), CRVE (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), lower BMI (<jats:italic>P<\/jats:italic>\u2009=\u20090.015), older age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) smaller disc area (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and higher TLCPD (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). When age and\/or BMI were omitted from the model, reduced RA was also associated with lower CSFP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Reduced RA is associated with narrow CRVE and higher IOP or lower CSFP. The data supports the concurrent role of IOP\u2010related and vascular factors in glaucomatous optic nerve damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13042","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T13:32:38Z","timestamp":1504186358000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of intraocular pressure\u2010related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma"],"prefix":"10.1111","volume":"46","author":[{"given":"Qing","family":"Zhang","sequence":"first","affiliation":[{"name":"Capital Medical University, Ophthalmology and Visual Science Key Lab Beijing 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