{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:48:42Z","timestamp":1774954122181,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>The XEN\u201045 implant, a hydrophilic collagen implant which drains aqueous to the subconjunctival space, has not been investigated in the context of uveitic glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the safety and efficacy of the XEN\u201045 collagen implant in eyes with uveitic glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Exploratory prospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>patients with medically uncontrolled uveitic glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four consecutive patients (mean age\u2009\u00b1\u2009standard deviation [SD]\u2009=\u200945.3\u2009\u00b1\u200918.1\u2009years) were implanted with the XEN\u201045 implant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The primary outcome measure was intraocular pressure (IOP) reduction at 12\u2009months as compared to baseline. Secondary outcome measures included ocular hypotensive medication use at 12\u2009months, the requirement for further glaucoma surgery and failure. Intraoperative and postoperative complications were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline mean\u2009\u00b1\u2009SD IOP was 30.5\u2009\u00b1\u20099.8\u2009mmHg and the mean\u2009\u00b1\u2009SD number of glaucoma medications required was 3.3\u2009\u00b1\u20090.8. In 20 eyes (83.3%) in whom conventional glaucoma surgery was originally perceived to be inevitable, further surgery was not required after XEN\u201045 implantation. The mean IOP was reduced by 60.2% from baseline to 12.2\u2009\u00b1\u20093.1\u2009mmHg and mean medication usage was reduced to 0.4\u2009\u00b1\u20090.9 at 12\u2009months (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). One patient had hypotony persisting beyond 2 months that required surgical revision and one patient developed blebitis. The 12\u2010month cumulative Kaplan\u2013Meier survival probability was 79.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The XEN\u201045 implant is effective for the treatment of patients with medically uncontrolled uveitic glaucoma. Potentially sight\u2010threatening complications, including bleb\u2010related ocular infection and persistent hypotony, may occur.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13087","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T14:36:40Z","timestamp":1508510200000},"page":"339-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["XEN\u201045 collagen implant for the treatment of uveitic glaucoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-6019","authenticated-orcid":false,"given":"Chelvin CA","family":"Sng","sequence":"first","affiliation":[{"name":"Glaucoma Service Moorfields Eye Hospital  London UK"},{"name":"Department of Ophthalmology National University Health System  Singapore Singapore"},{"name":"Singapore Eye Research Institute  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Glaucoma Service Moorfields Eye Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Hau","sequence":"additional","affiliation":[{"name":"Glaucoma Service Moorfields Eye Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hla Myint","family":"Htoon","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Barton","sequence":"additional","affiliation":[{"name":"Glaucoma Service Moorfields Eye Hospital  London UK"},{"name":"Department of Ophthalmology National University Health System  Singapore Singapore"},{"name":"National Institute for Health Research, Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital  London UK"},{"name":"Institute of Ophthalmology University College  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.01.032"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32834ff1e7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.11.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.06.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.774424"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000136"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(02)00028-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71349-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00351-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30527-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3129\/can j ophthalmol.06-124"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.09.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.238"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3129\/i09.080"},{"key":"e_1_2_5_17_1","first-page":"389","article-title":"Gonioscopy","volume":"2","author":"Shaffer RN","year":"1957","journal-title":"Surv Ophthalmol"},{"key":"e_1_2_5_18_1","first-page":"112","article-title":"Primary glaucomas. 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