{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:33:56Z","timestamp":1757702036094,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31140025","31271045"],"award-info":[{"award-number":["31140025","31271045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>There is limited literature on paediatric donors in endothelial keratoplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the efficacy of and appropriate paediatric donor age for Descemet\u2019s stripping endothelial keratoplasty (DSEK).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective and observational case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010eight consecutive patients underwent DSEK with paediatric donor corneas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The age of the donors ranged from 32\u2009weeks gestation (premature neonate) to 3 years old. All donor consents were obtained from the parents. The causes of donor death included traffic accident, congenital heart disease and neonatal respiratory distress syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The outcome measures included best\u2010corrected visual acuity, endothelial cell loss and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Best\u2010corrected visual acuity at last follow\u2010up was &gt;20\/40 in 28 of 38 eyes (73.7%). The mean preoperative endothelial cell density of donor corneas was 4682\u2009\u00b1\u2009520 cells\/mm<jats:sup>2<\/jats:sup>. The mean endothelial cell density of grafts was 3977\u2009\u00b1\u2009556 cells\/mm<jats:sup>2<\/jats:sup> at 18\u2009months postoperatively. Three lenticules from premature neonate donors exhibited severe contraction postoperatively. The edge of six lenticules from donors &lt;1\u2010year\u2010old exhibited contraction in the early postoperative period and gradually flattened spontaneously. Graft detachment occurred in one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>DSEK with paediatric donor corneas can achieve good clinical outcomes. The corneal lenticules from 1\u2010 to 3\u2010year\u2010 old donors are suitable for DSEK while those from donors &lt;1\u2010year\u2010old are less suitable due to the possibility of severe postoperative graft contraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13186","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T05:32:44Z","timestamp":1519968764000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical outcomes after Descemet\u2019s stripping endothelial keratoplasty using donor corneas from children younger than 3 years"],"prefix":"10.1111","volume":"46","author":[{"given":"Rong\u2010mei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Key Laboratory of Vision Loss and Restoration Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Key Laboratory of Vision Loss and Restoration Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-3963","authenticated-orcid":false,"given":"Yuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Key Laboratory of Vision Loss and Restoration Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-6497","authenticated-orcid":false,"given":"Jing","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Key Laboratory of Vision Loss and Restoration Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u2010ge","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Key Laboratory of Vision Loss and Restoration Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010qiang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Key Laboratory of Vision Loss and Restoration Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.8.1133"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.08.012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181c11e5d"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.06.033"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318247311a"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000921"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.12.029"},{"key":"e_1_2_5_10_1","first-page":"312","article-title":"Prenatal and postnatal cellularity of the human corneal endothelium. 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