{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:19:01Z","timestamp":1762899541703,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>The effect of subconjunctival Bevacizumab injection on the outcome of Ahmed glaucoma valve (AGV) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Evaluation of efficacy and safety of subconjunctival Bevacizumab injection adjunctive to AGV implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective and randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Fifty eyes of 50 patients with diagnosis of glaucoma that were candidate for AGV surgery were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 25 eyes, conventional AGV surgery (group 1) and in 25 eyes AGV surgery with subconjunctival Bevacizumab (group 2) was performed by block randomization<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The primary outcome measure was surgical success. Outcome measures were compared at postoperative month 3, 6 and 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of patients was 58.76 \u00b1 12.11 and 51.36 \u00b1 15.44 years in group 1 and 2 respectively (<jats:italic>P<\/jats:italic> = 0.06). Mean intraocular pressure (IOP) at baseline was 24.88\u2009\u00b1 7.62\u2009mmHg in group 1 and 27.52\u2009\u00b1 8.57\u2009mmHg in group 2 which decreased to15.4 \u00b1 4.4 mmHg in group 1 and 13.42\u2009\u00b1 2.9 mmHg in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.00) at last follow up. Surgical success was defined in two level: postoperative IOP \u2264\u200921\u2009mmHg with at least 20% reduction in IOP (Criterion A), either with no medication (complete success) or with no more than two medications (qualified success) and criterion B with the same definition but the IOP \u2264\u200918\u2009mmHg The cumulative success according to criterion A and B was 77.8%, 72.2% in group 1 and 89.5% in group 2, respectively, at the end of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Subconjunctival injection of Bevacizumab adjunctive to AGV implantation leads to higher success rate compared with AGV alone in one year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13191","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T06:06:52Z","timestamp":1521871612000},"page":"750-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of subconjunctival Bevacizumab injection on the outcome of Ahmed glaucoma valve implantation: a randomized control trial"],"prefix":"10.1111","volume":"46","author":[{"given":"Arezoo","family":"Miraftabi","sequence":"first","affiliation":[{"name":"Eye Research Center Rassoul Akram Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Nilforushan","sequence":"additional","affiliation":[{"name":"Eye Research Center Rassoul Akram Hospital, Iran University of Medical Sciences  Tehran 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