{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:11:26Z","timestamp":1792098686913,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102017\u20100149"],"award-info":[{"award-number":["6\u20102017\u20100149"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>\n \n Importance<\/jats:title>\n There is no consensus on the optimal management of submacular haemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV).<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n To compare the long\u2010term outcome of three treatment strategies for PCV with SMH.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective case series at two tertiary hospitals.<\/jats:p>\n <\/jats:sec>\n \n Samples<\/jats:title>\n A total of 48 consecutive eyes treated between July 2006 and March 2016.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients were grouped according to the treatment received: 22 eyes with intravitreal bevacizumab (IVB), 14 with a combination of IVB and pneumatic displacement (PD) and 12 with IVB and vitrectomy (TPPV).<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Change in best\u2010corrected visual acuity (BCVA) at onset and up to 24\u2009months. Secondary measures included demographic data, imaging data and complications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Comparing the mean BCVAs of the groups revealed significant differences only at month 1 (\n P<\/jats:italic>\n =\u20090.005). Changes in the mean BCVA over time revealed no significance in the resulting final BCVA (\n P<\/jats:italic>\n =\u20090.062), which was 20 out of 155 (logMAR 0.89\u2009\u00b1\u20090.64) for IVB monotherapy, 20 out of 174 (0.94\u2009\u00b1\u20091.04) for combined IVB\u2009+\u2009PD, and 20 out of 195 (0.99\u2009\u00b1\u20090.90) for combined IVB\u2009+\u2009TPPV eyes. Sustained long\u2010term improvement of over three Snellen lines was found in seven (31.82%) IVB monotherapy, 10 (71.43%) combined IVB\u2009+\u2009PD, and seven (58.33%) combined IVB\u2009+\u2009TPPV eyes (\n P<\/jats:italic>\n =\u20090.043). SMH recurrence was observed in two eyes after IVB monotherapy and one eye after combined IVB\u2009+\u2009PD (\n P<\/jats:italic>\n =\u20090.786).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n IVB monotherapy appears to be as effective as combination therapies for treating SMH secondary to PCV with regards to BCVA at 24\u2009months, and may be a cost\u2010effective strategy for long\u2010term management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ceo.13198","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T11:08:47Z","timestamp":1523617727000},"page":"916-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term visual outcomes for treatment of submacular haemorrhage secondary to polypoidal choroidal vasculopathy"],"prefix":"10.1111","volume":"46","author":[{"given":"Hyun Goo","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunseung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Ho","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Jun","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-6959","authenticated-orcid":false,"given":"Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199001010-00001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2003.10.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31824f91e8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.186"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.5.479"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305674"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080050139046"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.06.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2474126416680670"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.10.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.032466"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2016.30.3.192"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343066"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00078-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S8635"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2010.0066"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01404-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181c969e9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000574"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S55413"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.164707"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.04.004"}],"container-title":["Clinical & Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.13198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.13198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:57:29Z","timestamp":1693969049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.13198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/ceo.13198"],"URL":"https:\/\/doi.org\/10.1111\/ceo.13198","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"2018-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}