{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:18:04Z","timestamp":1790198284506,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondazione Roma"},{"name":"Italian Ministry of Health"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>The contribution of the microvascular supply to the pathogenesis of Leber's hereditary optic neuropathy (LHON) is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT\u2010A) at different stages of LHON.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, cross\u2010sectional, multicenter, observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Twenty\u2010two LHON patients divided in four groups: unaffected mutation carriers (LHON\u2010u); early sub\u2010acute stage (LHON\u2010e); late sub\u2010acute stage (LHON\u2010l); chronic stage (LHON\u2010ch).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OCT\u2010A scans centred on the optic disc were obtained by spectral domain OCT system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>VD, retinal nerve fibre layer (RNFL) and ganglion cell\u2010inner plexiform layer (GC\u2010IPL) thickness were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant VD changes were detected in every sector (<jats:italic>P<\/jats:italic> &lt; 0.0001). In LHON\u2010e, the VD was reduced in the temporal sector compared with LHON\u2010u and in the temporal and inferotemporal sectors compared with controls. In LHON\u2010l, VD was reduced in whole, temporal, superotemporal and inferotemporal sectors compared with LHON\u2010u and controls. In LHON\u2010ch, the VD was reduced in all sectors compared to the other groups. An asynchronous pattern emerged in the temporal sector with VD changes occurring earlier than RNFL thickness changes and together with GC\u2010IPL thinning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Significant peripapillary miscrovascular changes were detected over the different stages of LHON. Studying the vascular network separately from fibres revealed that microvascular changes in the temporal sector preceded the changes of RNFL and mirrored the GC\u2010IPL changes. Measurements of the peripapillary vascular network may become a useful biomarker to monitor the disease process, evaluate therapeutic efficacy and elucidate pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13326","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T05:19:05Z","timestamp":1527052745000},"page":"1055-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2625-2244","authenticated-orcid":false,"given":"Nicole","family":"Balducci","sequence":"first","affiliation":[{"name":"Studio Oculistico d'Azeglio  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Cascavilla","sequence":"additional","affiliation":[{"name":"Scientific Institute 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